EXPRESSION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR IN THE REGENERATING RAT-LIVER
EXPRESSION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR IN THE REGENERATING RAT-LIVER
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DOI：
10.1016/0304-3835(93)90106-j
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发表时间：
1993-07-30
期刊：
影响因子：
9.7
通讯作者：
SATO, C
中科院分区：
文献类型：
--
作者：
HOSHINO, Y;ENOMOTO, N;SATO, C
c-met癌基因产物是一种细胞表面受体，其配体被认为是肝细胞生长因子。我们研究了部分肝切除或 CCl4 诱导的肝损伤后再生大鼠肝脏中 c-met 癌基因的表达。 Northern blot分析显示，部分肝切除后，c-met转录本在8小时时下降，36小时时达到最低，并在第7天恢复到稳定水平。与肝切除的肝脏相反，CCl4处理后c-met的转录物增加。这些观察结果表明，c-met 转录可能根据再生信号受到不同的调节。
The c-met oncogene product is a cell-surface receptor, which ligand is believed to be the hepatocyte growth factor. We studied the expression of c-met oncogene in the regenerating rat liver after either partial hepatectomy or CCl4-induced liver injury. Northern blot analysis showed that after partial hepatectomy the transcripts of c-met decreased at 8 h, reached the minimum at 36 h, and returned to the steady level on the seventh day. In contrast with the hepatectomized liver, the transcripts of c-met increased after CCl4 treatment. These observations suggest that c-met transcription may be regulated differently depending on regeneration signals.