Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials
Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials
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DOI：
10.1093/ndt/gfz023
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发表时间：
2019-07-01
影响因子：
6.1
通讯作者：
Wanner, Christoph
中科院分区：
文献类型：
--
作者：
Zoccali, Carmine;Blankestijn, Peter J.;Wanner, Christoph
将慢性肾脏疾病(CKD)患者排除在临床试验之外--特别是心血管试验--仍然是一个长期未解决的问题，阻碍了这些患者的临床护理的优化。这种情况让人想起，在1980年代之前，心血管试验中没有充分招募妇女，这个问题只是在监管干预后才得到解决。监管机构在促进临床试验中招募CKD患者方面处于独特的地位。主要利益相关者，即患者协会和科学协会，应该做出重大游说努力，说服这些机构，这个问题是绝对的公共卫生优先事项。
The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.