Abnormal corticostriatal activity during fear perception in bipolar disorder.
Abnormal corticostriatal activity during fear perception in bipolar disorder.
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DOI：
10.1097/wnr.0b013e328310af58
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发表时间：
2008-10-08
期刊：
影响因子：
1.7
通讯作者：
Yurgelun-Todd DA
中科院分区：
文献类型：
--
作者：
Killgore WD;Gruber SA;Yurgelun-Todd DA
对情感刺激的重复呈现的反应的时程在健康个体中得到很好的表征，但在双相情感障碍患者中仍有待表征。使用功能性磁共振成像（fMRI），我们比较了早期和晚期的大脑激活过程中的两块可怕的面孔知觉任务在14个成年双相情感障碍患者的13个健康对照。而对照组显示增加眶额，前扣带回，纹状体活动在后期（与早期）阶段的任务，双相情感障碍患者未能显示正常的任务相关的活动，在这些地区。结果表明，双相情感障碍可能涉及皮质-纹状体功能障碍。
The time-course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging (fMRI), we compared early- and late-stage brain activation during a two-block fearful face perception task in 14 adult bipolar patients to that of 13 healthy controls. Whereas control subjects showed increased orbitofrontal, anterior cingulate, and striatum activity during the late (versus early) stage of the task, bipolar patients failed to show normal task-related activity in these regions. Results suggest that bipolar disorder may involve cortico-striatal dysfunction.