Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer.
Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer.
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DOI：
10.1002/wnan.1528
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Oupický D
中科院分区：
文献类型：
--
作者：
Xie Y;Wang Y;Li J;Hang Y;Oupický D
趋化因子和趋化因子受体在癌症进展和转移中起关键作用。尽管已经研究了多种趋化因子和趋化因子受体，但抑制CXCR4成为联合癌症治疗中最有前途的方法之一，特别是当集中于转移性疾病时。小RNA分子，如siRNA和miRNA，代表了通过RNA干扰介导的基因沉默治疗癌症的新一类疗法。然而，由于缺乏有效的递送系统，siRNA和miRNA的临床应用受到严重限制。靶向CXCR4的纳米药物与siRNA和miRNA的递送组合在癌症中具有显著的治疗潜力。本文介绍了最近开发的CXCR4靶向聚合物药物和纳米药物，包括基于cyclam和氯喹的聚合物CXCR4拮抗剂，并讨论了它们递送功能性siRNA和miRNA的能力。
Chemokines and chemokine receptors play key roles in cancer progression and metastasis. Although multiple chemokines and chemokine receptors have been investigated, inhibition of CXCR4 emerged as one of the most promising approaches in combination cancer therapy, especially when focused on the metastatic disease. Small RNA molecules, such as siRNA and miRNA, represent new class of therapeutics for cancer treatment through RNA interference-mediated gene silencing. However, the clinical applicability of siRNA and miRNA is severely limited by the lack of effective delivery systems. There is a significant therapeutic potential for CXCR4-targeted nanomedicines in combination with the delivery of siRNA and miRNA in cancer. Recently developed CXCR4-targeted polymeric drugs and nanomedicines, including cyclam- and chloroquine-based polymeric CXCR4 antagonists are introduced here and their ability to deliver functional siRNA and miRNA is discussed.
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DOI：
10.4161/cc.9.6.11006
发表时间：
2010-03-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Chan SY;Loscalzo J
通讯作者：
Loscalzo J
DOI：
10.1016/j.omtn.2017.06.005
发表时间：
2017-09-15
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Chakraborty C;Sharma AR;Sharma G;Doss CGP;Lee SS
通讯作者：
Lee SS
影响因子：
16.6
作者：
Gallo, Juan;Kamaly, Nazila;Lavdas, Ioannis;Stevens, Elizabeth;Quang-De Nguyen;Wylezinska-Arridge, Marzena;Aboagye, Eric O.;Long, Nicholas J.
通讯作者：
Long, Nicholas J.
影响因子：
7.3
作者：
Bridger, Gary J.;Skerlj, Renato T.;Schols, Dominique
通讯作者：
Schols, Dominique
影响因子：
120.1
作者：
De Clercq, E
通讯作者：
De Clercq, E