CHEMICAL-STRUCTURE OF LIPID A FROM PORPHYROMONAS (BACTEROIDES) GINGIVALIS LIPOPOLYSACCHARIDE
CHEMICAL-STRUCTURE OF LIPID A FROM PORPHYROMONAS (BACTEROIDES) GINGIVALIS LIPOPOLYSACCHARIDE
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DOI：
10.1016/0014-5793(93)80512-s
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发表时间：
1993-10-11
期刊：
影响因子：
3.5
通讯作者：
OGAWA, T
中科院分区：
文献类型：
--
作者：
OGAWA, T
牙龈卟啉单胞菌381菌脂A的化学结构经鉴定为氨基葡萄糖β-(1-6)二糖1-单磷酸，分别由3-羟基-15-甲基十六酸和3-十六烷氧基-15-甲基十六酸在2‘-位和2’-位酰化而成。脂肪A在4‘-位没有酯连接的磷酸盐，在3-和3’-位没有脂肪酸，以及含有16-17个碳原子的脂肪酸，这是区别于肠道细菌和其他脂质AS的独特特征。这些结构特征可能与其内毒素活性低有关。更重要的是。牙龈假单胞菌类脂A及其脂多糖刺激C3H/HEN和C3H/HeJ小鼠的脾细胞。
The novel chemical structure of Porphyromonas (Bacteroides) gingivalis strain 381 lipid A was determined to be a glucosamine beta-(1-6) disaccharide 1-monophosphate acylated by 3-hydroxy-15-methylhexadecanoic acid and 3-hexadecanoyloxy-15-methylhexadecanoic acid at the 2- and 2'-positions, respectively. The absence of ester-linked phosphate at thc 4'-position and fatty acids at the 3- and 3'-positions, and the presence of fatty acids possessing 16-17 carbon atoms are unique features, differentiating the lipid A from enterobacterial and other lipid As. These structural features may be related to its low endotoxic activity. Furthermore. P. gingivalis lipid A as well as its LPS stimulated the splenocytes from C3H/HeN and C3H/HeJ mice.