Tear film break-up time evaluated by real-time Hartmann-Shack wavefront sensing
Tear film break-up time evaluated by real-time Hartmann-Shack wavefront sensing
复制标题
DOI：
10.1007/s10384-005-0289-6
复制
发表时间：
2006-03-01
影响因子：
2.4
通讯作者：
Fujikado, T
中科院分区：
文献类型：
--
作者：
Mihashi, T;Hirohara, Y;Fujikado, T
目的：建立一种利用哈特曼-夏克（Hartmann-Shack，H-S）像差仪连续测量高阶波前像差来测量泪膜破裂时间（tear breakup time，BUT）的新方法。在表面麻醉下每秒进行一次畸变检查，持续50 s。将点序列分为两个阶段，并将BUT定义为阶段的波前边界（WFBUT）。将WFBUT与常规荧光素法（FFBUT）及平静环破坏法（PLBUT）检测的BUT进行比较。WFBUT（平均10.9 ± 1.1s）短于PLBUT（平均17.5 ± 2.5s），而在其他3只眼中，WFBUT（平均21.5 ± 2.2s）长于PLBUT（平均）。8.1+/- 2.2s）。结论：H-S像差仪测量泪膜破裂时间可作为泪膜破裂时间的实用测量方法。
Purpose:To develop a novel method for measuring tear break-up time (BUT) by continuously measuring higher order wavefront aberrations using a Hartmann-Shack (H-S) aberrometer.Methods: Wavefront aberrations up to the sixth order for a 4-mm pupil were measured in six eyes of six normal subjects using an H-S aberrometer. The aberronictry was performed once every second for up to 50s under topical anesthesia. The sequence of the points was divided into two stages, and the BUT was defined as the wavefront border of the stages (WFBUT). The WFBUT was compared with the BUT by the conventional fluorescein method (FLBUT) or by the disruption of placid-ring images (PLBUT).Results: In three eyes. the WFBUT (average, 10.9 +/- 1.1s) was shorter than the PLBUT (average, 17.5 +/- 2.5s), while in the other three eyes the WFBUT (average, 21.5 +/- 2.2s) was longer than PLBUT (average. 8.1 +/- 2.2s). The FLBUT was shorter than WFBUT or PLBUT in most cases.Conclusions: The tear break-LIP time measured by H-S aberrometer may be used as a practical measure of tear break-LIP.