A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature.
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature.
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DNA多态性分析诊断妊娠期卵巢绒毛膜癌一例报告及系统文献复习
DOI：
10.1186/s13048-017-0334-3
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发表时间：
2017-07-20
影响因子：
4
通讯作者：
Feng W
中科院分区：
文献类型：
--
作者：
Jia N;Chen Y;Tao X;Ou E;Lu X;Feng W
卵巢绒毛膜癌是罕见的。这种肿瘤可以起源于妊娠组织或卵巢的纯生殖细胞，前者导致妊娠绒毛膜癌。这两种肿瘤的临床特征和组织学类型是相同的，这些肿瘤的分化是有效治疗的必要条件。区分这些肿瘤类型的一种策略是通过DNA多态性分析来鉴定父系DNA的存在。在本病例中，一名27岁的患者有闭经、下腹疼痛和阴道出血病史，根据异位妊娠的初步诊断，接受了腹腔镜下右侧卵巢囊性肿块剥离术。病理诊断为原发性卵巢绒毛膜癌，但其起源不确定。然后进行DNA多态性分析，并确认妊娠起源。患者随后表现出对化疗的良好反应，达到完全缓解，并生下了一个健康的婴儿。原发性绒毛膜癌的两种病因之间的区分可以通过DNA多态性分析来实现，并且有必要区分它们以接近患者的适当治疗。
Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to identify the presence of paternal DNA by DNA polymorphic analysis. In the present case, a 27-year-old patient with a history of amenorrhea, lower abdominal pain and vaginal bleeding received a laparoscopic dissection of cystic mass of the right ovary according to an initial diagnosis of ectopic pregnancy. Primary choriocarcinoma of the ovary was diagnosed by pathology, but its origin was uncertain. DNA polymorphic analysis was then performed and a gestational origin was confirmed. The patient subsequently exhibited an excellent response to chemotherapy, achieved complete remission and gave birth to a healthy baby. Differentiation between two etiologies of primary choriocarcinoma can be achieved with DNA polymorphic analysis and it is necessary to distinguish between them to approach to an appropriate treatment of a patient.
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