MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
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使用基于树状聚合物的造影剂进行 MR 淋巴管造影：1.5T 和 3.0T 的比较。
DOI：
10.1002/mrm.21126
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Kobayashi,Hisataka
中科院分区：
文献类型：
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作者：
Hama,Yukihiro;Bernardo,Marcelino;Regino,CelesteAS;Koyama,Yoshinori;Brechbiel,MartinW;Krishna,MuraliC;Choyke,PeterL;Kobayashi,Hisataka
大多数大分子造影剂（CA）在3.0T下的r1弛豫率低于1.5T下的r2弛豫率，而在3.0T下的r2弛豫率高于1.5T下的r1弛豫率。使用基于大分子G6树枝状聚合物的CA在小鼠中连续进行MR淋巴管造影，并在1.5T和3.0T下进行比较。在1.5T和3.0T下，G6 CA的r1和r2弛豫率分别为25和78/s/mM，17和82/s/mM。淋巴结（LN）与脂肪的比率T1加权3D快速扰相梯度回波的（LN信号强度（SI）/脂肪SI）（3D-FSPGR）为3.2 ± 0.4（平均值±标准差（SD）），1.5 T和2.7 ± 0.3，3.0 T（P= 0.021），以及采用相位循环稳态采集的T2/T1加权3D快速成像的LN/脂肪比（3D-FIESTA-C）在1.5 T时为1.8 ± 0.2，在3.0 T时为1.2 ± 0.4（P= 0.003）。尽管3D‐FSPGR在1.5T和3.0T下均成功描绘了LN，但3D‐FIESTA‐C在3.0T下未能可视化LN。Magn Reson Med 57：431-436，2007.© 2007 Wiley利斯公司
Most macromolecular contrast agents (CAs) show lower r1and higher r2relaxivities at 3.0T than at 1.5T. MR lymphangiography in mice using a macromolecular G6 dendrimer‐based CA was serially performed and compared at both 1.5T and 3.0T. The r1and r2relaxivities of the G6 CA were 25 and 78/s/mM at 1.5T and 17 and 82/s/mM at 3.0T, respectively. The lymph node (LN)‐to‐fat ratios (LN signal intensity (SI)/fat SI) ofT1‐weighted 3D‐fast spoiled gradient‐echo (3D‐FSPGR) were 3.2 ± 0.4 (mean ± standard deviation (SD)) at 1.5T and 2.7 ± 0.3 at 3.0T (P= 0.021), and the LN‐to‐fat ratios ofT2/T1‐weighted 3D‐fast imaging employing steady‐state acquisition with phase cycling (3D‐FIESTA‐C) were 1.8 ± 0.2 at 1.5T and 1.2 ± 0.4 at 3.0T (P= 0.003). Although 3D‐FSPGR successfully delineated the LNs at both 1.5T and 3.0T, 3D‐FIESTA‐C at 3.0T failed to visualize the LNs. Magn Reson Med 57:431–436, 2007. © 2007 Wiley‐Liss, Inc.