THE MESENCEPHALIC LOCOMOTOR REGION .2. PROJECTIONS TO RETICULOSPINAL NEURONS
THE MESENCEPHALIC LOCOMOTOR REGION .2. PROJECTIONS TO RETICULOSPINAL NEURONS
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DOI：
10.1016/0006-8993(87)90676-7
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发表时间：
1987-05-12
期刊：
影响因子：
2.9
通讯作者：
SKINNER, RD
中科院分区：
文献类型：
--
作者：
GARCIARILL, E;SKINNER, RD
在已知接收下降中脑运动区（MLR）输入的中腹侧延髓区域的细胞外记录单个神经元。发现大量（47%）这些细胞在刺激生理学上确定的 MLR 后接收短潜伏期顺向输入。在研究的中腹侧髓质神经元中，34% 被发现投射到脊髓（通过刺激腹外侧索后的逆向激活来确定）。 大约一半（总细胞数的 17%）的网状脊髓细胞被发现接收来自 MLR 的短潜伏期顺向输入。这组网状脊髓细胞的区域分布与之前的解剖学研究中发现的接受 MLR 下降投影的区域相对应。此外，在一项配套研究中，发现同一区域的电和化学激活可以引起跑步机上的运动。目前的研究结果表明，下降的 MLR 投射影响大量的腹内侧髓质细胞，其中一些细胞具有直接的脊髓投射，并表明该区域是 MLR 功能表现的主要中继。
Single neurons were recorded extracellularly in an area of the medioventral medulla known to receive descending mesencephalic locomotor region (MLR) input. A large number (47%) of these cells were found to receive short-latency orthodromic input following stimulation of the physiologically identified MLR. Of the medioventral medulla neurons studied, 34% were found to project to the spinal cord (determined by antidromic activation following stimulation of the ventrolateral funiculus). Approximately one-half (17% of the total population) of these reticulospinal cells were found to receive short-latency orthodromic input from the MLR. The regional distribution of this gorup of reticulospinal cells corresponded with the area found to receive descending projections from the MLR in previous anatomical studies. In addition, electrical and chemical activation of the same region was found to elicit locomotion on a treadmill in a companion study. The present findings demonstrate that descending MLR projections influence a large number of medioventral medulla cells, some of which have direct spinal projections, and suggest that this area is a primary relay in the manifestation of MLR function.