A CELL-CYCLE REGULATOR POTENTIALLY INVOLVED IN GENESIS OF MANY TUMOR TYPES
A CELL-CYCLE REGULATOR POTENTIALLY INVOLVED IN GENESIS OF MANY TUMOR TYPES
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DOI：
10.1126/science.8153634
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发表时间：
1994-04-15
期刊：
影响因子：
56.9
通讯作者：
SKOLNICK, MH
中科院分区：
文献类型：
--
作者：
KAMB, A;GRUIS, NA;SKOLNICK, MH
在黑色素瘤细胞系中，通过纯合缺失的方法，在人类9号染色体短臂上的一个假定的肿瘤抑制基因座已经定位于少于40个组氨酸酶的区域。该区域含有一个基因，多发性肿瘤抑制因子1（MTS 1），它编码一个以前鉴定的细胞周期蛋白依赖性激酶4的抑制剂（p16）。MTS1在肺、乳腺、脑、骨、皮肤、膀胱、肾、卵巢和淋巴细胞的肿瘤细胞系中以高频率同源缺失。黑色素瘤细胞系携带至少一个拷贝的MTS1经常携带无义，错义或移码突变的基因。这些发现表明，MTS1突变参与了广泛组织中的肿瘤形成。
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (pl 6) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.