Abnormal Hemispheric Blood Flow and Metabolism in Cerebrovascular Disease. II. Therapeutic Trials With 5% CO2 Inhalation, Hyperventilation and Intravenous Infusion of THAM and Mannitol
Abnormal Hemispheric Blood Flow and Metabolism in Cerebrovascular Disease. II. Therapeutic Trials With 5% CO2 Inhalation, Hyperventilation and Intravenous Infusion of THAM and Mannitol
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异常%20半球%20血液%20流量%20和%20代谢%20in%20脑血管%20疾病.%20II.%20治疗%20试验%20使用%205%%20CO2%20吸入%20过度换气%20和%20静脉%20输注%20的%20THAM%2 0和%
DOI：
10.1161/01.str.3.2.157
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发表时间：
1972
期刊：
影响因子：
8.3
通讯作者：
A. Ericsson
中科院分区：
文献类型：
--
作者：
J. Meyer;Y. Fukuuchi;K. Shimazu;T. Ohuchi;A. Ericsson
本文观察了吸入5%CO_2空气、主动过度通气、静脉滴注THAM和甘露醇对急性、慢性脑缺血患者和1例脑肿瘤患者缺血半球血流和代谢的影响。5%的CO2吸入增加了HBF，降低了缺血半球的半球RQ（HRQ）。过度通气会降低HBF并增加半球葡萄糖消耗。THAM输注对HBF和代谢没有影响，甘露醇增加HBF，但对缺血半球的代谢没有影响。在患有脑肿瘤的患者中，5%CO2吸入引起“脑内盗血”，这可能是由于颅内压升高和肿瘤肿胀半球的血液“挤压”或移位到正常半球的结果。静脉注射甘露醇通过暂时降低颅内压增加了肿瘤所在半球的血流量。
The effects of inhalation of 5% CO2 in air, active hyperventilation, and intravenous infusion of THAM and mannitol on hemispheric blood flow (HBF) and metabolism were investigated in the ischemic hemispheres of patients with acute and chronic cerebral ischemia and in one with brain tumor. Five percent CO2 inhalation increased HBF and decreased hemispheric RQ (HRQ) in the ischemic hemisphere. Hyperventilation decreased HBF and increased hemispheric glucose consumption. THAM infusion had no effect on HBF and metabolism, and mannitol increased HBF but had no effect on metabolism in the ischemic hemispheres. In the patient with brain tumor, 5% CO2 inhalation caused an “intracerebral steal” probably as a result of increasing intracranial pressure and “squeezing” or displacing of blood from the hemisphere swollen by tumor into the normal hemisphere. Intravenous injection of mannitol increased the blood flow to the hemisphere containing the tumor by temporarily reducing intracranial pressure.