HUMAN PAPILLOMAVIRUS-11 DNA IN A PATIENT WITH CHRONIC LARYNGOTRACHEOBRONCHIAL PAPILLOMATOSIS AND METASTATIC SQUAMOUS-CELL CARCINOMA OF THE LUNG
HUMAN PAPILLOMAVIRUS-11 DNA IN A PATIENT WITH CHRONIC LARYNGOTRACHEOBRONCHIAL PAPILLOMATOSIS AND METASTATIC SQUAMOUS-CELL CARCINOMA OF THE LUNG
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DOI：
10.1056/nejm198710013171406
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发表时间：
1987-10-01
影响因子：
158.5
通讯作者：
HOWLEY, PM
中科院分区：
文献类型：
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作者：
BYRNE, JC;TSAO, MS;HOWLEY, PM
喉乳头状瘤是一种良性的上皮性肿瘤，主要累及喉和会厌，但也可累及气管和支气管。与喉乳头状瘤病相关的浸润性鳞状细胞癌的发展是罕见的，几乎只发生在接受过放射治疗的患者中。1，2喉乳头状瘤是由特异性人乳头状瘤病毒（HPV）引起的，HPV对鳞状上皮细胞具有特异性嗜性，可诱导细胞增殖或异型增生。目前已鉴定出超过46种不同类型的HPV，其中两种与喉乳头状瘤有关。这些是HPV-11，最初被检测到。
LARYNGEAL papillomas are benign epithelial tumors that primarily involve the larynx and epiglottis but may extend into the trachea and the bronchi. The development of invasive squamous-cell carcinoma in association with laryngeal papillomatosis is rare and occurs almost exclusively in patients who have had radiation therapy.1,2Laryngeal papillomas are caused by specific human papillomaviruses (HPVs), which have a specific tropism for squamous epithelial cells and which can induce cellular proliferation or dysplasia.More than 46 distinct types of HPVs have been identified, and two of them have been specifically associated with laryngeal papillomas. These are HPV-11, which was originally detected . . .