Highly sensitive chiral shift reagent bearing two zinc porphyrins
Highly sensitive chiral shift reagent bearing two zinc porphyrins
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DOI：
10.1021/ol0514808
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发表时间：
2005-09-01
期刊：
影响因子：
5.2
通讯作者：
Sakai, T
中科院分区：
文献类型：
--
作者：
Ema, T;Ouchi, N;Sakai, T
合成了一种具有G对称性的新型手性受体(RR)-或(S，S)-1b。圆二色谱揭示了1b与二胺的诱导拟合型结合行为。核磁共振研究表明，1b可以作为一种高灵敏的手性位移试剂，在微克水平上用于手性二胺、氮杂环丙烷和异恶唑啉的对映体纯度的测定。
A new type of chiral receptor (RR)- or (S,S)-1b with G symmetry was synthesized. An induced-fit type of binding behavior of 1b for diamines was revealed by CD spectroscopy. NMR studies demonstrated that 1b can function as a highly sensitive chiral shift reagent for the determination of the enantiomeric purity of chiral diamines, aziridine, and isoxazoline at the microgram level.