Magnetic resonance-defined periportal steatosis following intraportal islet transplantation - A functional footprint of islet graft survival?
Magnetic resonance-defined periportal steatosis following intraportal islet transplantation - A functional footprint of islet graft survival?
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DOI：
10.2337/diabetes.52.7.1591
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发表时间：
2003-07-01
期刊：
影响因子：
7.7
通讯作者：
Naji, A
中科院分区：
文献类型：
--
作者：
Markmann, JF;Rosen, M;Naji, A
越来越多的人对更广泛地应用孤立胰岛移植治疗1型糖尿病感兴趣;然而，胰岛长期驻留在肝脏内的后遗症尚不清楚。我们在此报告门静脉内胰岛移植的结果，特别是门静脉周围肝脂肪变性的发展显然是由肝脏内胰岛素的局部分泌引起的。
There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.