An adaptive, Cartesian, front-tracking method for the motion, deformation and adhesion of circulating cells
An adaptive, Cartesian, front-tracking method for the motion, deformation and adhesion of circulating cells
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DOI：
10.1006/jcph.1998.5967
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发表时间：
1998-07-01
影响因子：
4.1
通讯作者：
Powell, KG
中科院分区：
文献类型：
--
作者：
Agresar, G;Linderman, JJ;Powell, KG
循环系统中的细胞通过分子相互作用和胶体斥力之间的竞争而附着，而细胞在外部流体力的存在下任意变形。所涉及的力的复杂耦合，它们作用的不同长度尺度，以及细胞变形机制中的不确定性，使得细胞黏附的研究变得复杂。为了解决这些困难，开发了一种具有交错、自适应细化网格的多流体前沿跟踪方法。作为研究细胞力学的工具，该程序允许在不显著改变设置的情况下合并和测试细胞的不同力学模型。作为一种研究细胞黏附的工具，该方法对相关作用力的耦合进行建模，以解决涉及的不同长度尺度。通过模拟各种算例对该方法进行了验证，结果与解析解和其他数值解吻合较好。通过对一种常见的细胞力学实验(微管实验)和一种常见的细胞黏附生理情况(两个细胞在剪切流下的黏附)的模拟，验证了该方法的能力。(C)1998年学术出版社。
Cells in circulatory systems adhere through a competition between molecular interactions and colloidal repulsion, while the cells arbitrarily deform in the presence of external fluid forces. The complex coupling of the forces involved, the disparate length scales at which they act, and uncertainties in the mechanics of cell deformation have complicated the study of cell adhesion. To address these difficulties, a multi-fluid, front-tracking method with staggered, adaptively refined meshes has been developed. As a tool to study cell mechanics, the program allows the incorporation and testing of different mechanical models of the cell without significant changes in the setup. As a tool to study cell adhesion, the method models the coupling of the relevant forces resolving the disparate length scales involved. The method was validated by simulating various test cases, and the results were found to agree well with analytical and other numerical solutions. The capabilities of the method are demonstrated with the simulation of a common cell-mechanics experiment (a micropipet assay) and a common physiological situation for cell adhesion (the adhesion of two cells under shear flow). (C) 1998 Academic Press.