How to build a molecular shock absorber.

How to build a molecular shock absorber.
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如何构建分子减震器。

DOI:
10.1016/s0960-9822(00)80075-5
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发表时间:
1999
期刊:
Current biology : CB
影响因子:
--
通讯作者:
McGough,A
McGough,A
中科院分区:
--
文献类型:
--
作者:
McGough,A

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新确定的α-螺旋重复序列的结构构成了血影蛋白和α-辅肌动蛋白的关键“杆”结构域,它们作为肌动蛋白结合结构域之间的间隔区,为了解这些蛋白质如何在细胞中发挥分子减震器的作用提供了重要的见解。
Newly determined structures of the α-helical repeats that make up the key ‘rod' domains of spectrin and α-actinin – which serve as spacers between their actin-binding domains – have provided important insights into how these proteins function as molecular shock absorbers in cells.