Analogue simulation of pharyngeal airflow response to Twin Block treatment in growing patients with Class II1 and mandibular retrognathia
Analogue simulation of pharyngeal airflow response to Twin Block treatment in growing patients with Class II1 and mandibular retrognathia
复制标题
对 II(1) 类和下颌后缩患者的咽部气流对 Twin Block 治疗的反应进行模拟模拟。
DOI：
10.1038/srep26012
复制
发表时间：
2016-05-18
影响因子：
4.6
通讯作者：
Liu, Dongxu
中科院分区：
文献类型：
--
作者：
Li, Liang;Wu, Wei;Liu, Dongxu
呼吸气流的流动特性是影响上气道通气功能的基本因素。本研究旨在通过计算流体动力学（CFD）模拟研究Twin Block（TB）治疗生长期安氏Ⅱ 1类下颌后缩患者后的咽部流场特征。对已完成TB治疗（n = 30）和即将接受TB治疗（n = 30）的患者进行锥形束计算机断层扫描（CBCT）重建。通过CFD模拟，进一步分析了咽部压降与形态参数之间的相关性。在吸气过程中，我们发现压力最小值发生在下咽部，而最大的压降和速度位于口咽部。TB治疗后，口咽部和下咽部的气流特征有明显差异，其中口咽部的变化最明显。口咽部压力降的变化量与口咽部的容积（r = 0.694，p = 0.001）、平均截面积（r = 0.859，p = 0.000）、最小截面积与平均截面积的比值（r = 0.898，p = 0.000）呈显著相关。本研究结果提示，下颌前伸后，咽部气流特征随下颌前伸的增大而增大，其体积、横截面积增大，口咽部面积分布更加均匀。
The flow dynamics of respiratory airflow is the basic factor that influences the ventilation function of the upper airway. This research aimed to investigate the pharyngeal flow field characteristics after Twin Block (TB) treatment in growing patients with Class II1 and mandibular retrognathia by computation fluid dynamics (CFD) simulation. Cone beam computed tomography (CBCT) scans of patients who have completed TB treatment (n = 30) and about to accept TB treatment (n = 30) were reconstructed. After CFD simulation, correlations between the pharyngeal pressure drop and morphological parameters were further analyzed. During inspiration, we found that the pressure minimum occurred in the hypopharynx, while the maximum pressure drop and velocity was located in the oropharynx. After TB treatment, the oropharynx and hypopharynx showed significant differences in airflow features, and the most obvious change was observed in the oropharynx. A significant correlation was discovered between the change amount of oropharyngeal pressure drop and volume (r = 0.694, p = 0.001), mean cross-sectional area (r = 0.859, p = 0.000), and ratio of the minimum and mean cross-sectional area (r = 0.898, p = 0.000) of the oropharynx. Our research suggested that the pharyngeal airflow characteristics response positively to mandibular advancement with the enlargement in volume, cross-sectional area and more uniform oropharyngeal area distribution.