Effect of postmenopausal hormone therapy on cognitive function: The heart and estrogen/progestin replacement study
Effect of postmenopausal hormone therapy on cognitive function: The heart and estrogen/progestin replacement study
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DOI：
10.1016/s0002-9343(02)01270-6
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发表时间：
2002-11-01
影响因子：
5.9
通讯作者：
Barrett-Connor, E
中科院分区：
文献类型：
--
作者：
Grady, D;Yaffe, K;Barrett-Connor, E
目的：确定激素疗法是否能使老年绝经后女性的认知功能更好。
受试者与方法：心脏和雌激素/孕激素替代研究（HERS）是一项随机、安慰剂对照试验，涉及2763名患有冠心病的女性。女性被随机分配到每日服用一片含结合雌激素（0.625毫克）加醋酸甲羟孕酮（2.5毫克）的药物组或相同的安慰剂组；对她们随访的平均（±标准差）时间为4.2±0.4年。20个HERS中心中的10个中心的参与者被邀请参加认知功能子研究。在试验结束时，我们使用六项标准测试对激素组的517名女性和安慰剂组的546名女性进行了认知功能测量：改良的简易精神状态检查表、语言流畅性测试、波士顿命名测试、单词列表记忆测试、单词列表回忆测试和连线测验B。在基线时未测量认知功能。
结果：进行认知功能测试时参与者的平均年龄为71±6岁。两个治疗组之间经年龄调整后的认知功能测试分数没有差异，除了被分配到激素组的女性在语言流畅性测试中的得分比被分配到安慰剂组的女性更差（15.9±4.8比16.6±4.8，P = 0.02）。对其他潜在混杂因素进行调整以及将分析限制在一直坚持服用研究药物的女性中，结果没有改变。
结论：在患有冠心病的老年绝经后女性中，绝经后激素疗法治疗4年并没有使六项标准化测试所测量的认知功能更好。本研究无法确定这些结果是否也适用于没有冠心病的老年女性。（C）2002年，由爱思唯尔出版公司出版
注释：Excerpta Medica, Inc.是荷兰爱思唯尔出版集团（Elsevier）的前身之一，此处翻译为“爱思唯尔出版公司”符合其历史和行业认知。
PURPOSE: To determine if hormone therapy results in better cognitive function in older postmenopausal women.SUBJECTS AND METHODS: The Heart and Estrogen/progestin Replacement Study (HERS) was a randomized, placebo-controlled trial involving 2763 women with coronary disease. Women were assigned randomly to conjugated estrogen (0.625 mg) plus medroxyprogesterone acetate (2.5 mg) in one tablet daily or identical placebo; they were followed for a mean (+/-SD) of 4.2 +/- 0.4 years. Participants at 10 of the 20 HERS centers were invited to enroll in the cognitive function substudy. At the end of the trial, we measured cognitive function in 517 women in the hormone group and 546 in the placebo group using six standard tests: the modified Mini-Mental Status Examination, Verbal Fluency, Boston Naming, Word List Memory, Word List Recall, and Trails B. Cognitive function was not measured at baseline.RESULTS: The mean age of participants at the time of cognitive function testing was 71 +/- 6 years. There were no differences in age-adjusted cognitive function test scores between the two treatment groups, except that women assigned to hormones scored worse on the Verbal Fluency test than women assigned to placebo (15.9 +/- 4.8 vs. 16.6 +/- 4.8, P = 0.02). Adjustment for other potential confounders and restriction of the analyses to women who had been adherent to study medication did not change the results.CONCLUSION: Among older postmenopausal women with coronary disease, 4 years of treatment with postmenopausal hormone therapy did not result in better cognitive function as measured on six standardized tests. Whether these results also apply to elderly women without coronary disease cannot be determined from this study. (C) 2002 by Excerpta Medica, Inc.