Soya isoflavone supplementation enhances spatial working memory in men
Soya isoflavone supplementation enhances spatial working memory in men
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DOI：
10.1017/s0007114509990201
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发表时间：
2009-11-14
影响因子：
3.6
通讯作者：
Howe, Peter R. C.
中科院分区：
文献类型：
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作者：
Thorp, Alicia A.;Sinn, Natalie;Howe, Peter R. C.
女性在某些与记忆有关的任务中表现得比男性更好。认知表现的性别差异可能归因于作用于雌激素β受体（ER β）的循环雌激素的差异，ER β受体在大脑区域如海马体、额叶和皮质中普遍存在，介导认知功能。由于已知大豆异黄酮可以激活ER β，因此男性长期补充维生素E可能会改善记忆相关任务的认知表现。在34名健康男性中进行了一项为期12周的双盲、安慰剂对照交叉试验，以研究补充维生素A对认知功能的影响。志愿者被随机分配到服用4粒含有大豆异黄酮的胶囊/天（116毫克大豆异黄酮当量/天：68毫克大豆苷元，12毫克染料木黄酮，36毫克黄豆苷）或安慰剂6周，并在接下来的6周内交替治疗。在基线和每个治疗期后评估记忆（言语情景、听觉和工作）、执行功能（计划、注意力、精神灵活性）和视觉空间处理。异黄酮的补充显着改善空间工作记忆（P=0.01），测试中，女性始终表现优于男性。与安慰剂补充剂相比，正确识别必要信息所需的尝试次数减少18%（P=0.01），错误减少23%（P=0.02），时间减少17%（P=0.03）。异黄酮并不影响听觉和情景记忆（配对联想学习，雷伊的听觉言语学习任务，向后数字广度和字母数字排序），执行功能（线索制作和初始字母流畅性任务）或视觉空间处理（心理旋转任务）。健康男性补充异黄酮可能会增强认知过程，这似乎依赖于雌激素激活。
Females perform better in certain memory-related tasks than males. Sex differences in cognitive performance may be attributable to differences in circulating oestrogen acting on oestrogen beta receptors (ER beta) which are prevalent in brain regions such as the hippocampus, frontal lobe and cortex that mediate cognitive functions. Since soya isoflavones are known to activate ER beta, chronic isoflavone supplementation in males may improve cognitive performance in memory-related tasks. A 12-week double-blind, placebo-controlled cross-over trial was conducted in thirty-four healthy men to investigate the effect of isoflavone supplementation on cognitive function. Volunteers were randomised to take four capsules/d containing soya isoflavones (116 mg isoflavone equivalents/d: 68 mg daidzein, 12 mg genistein, 36 mg glycitin) or placebo for 6 weeks, and the alternate treatment during the following 6 weeks. Assessments of memory (verbal episodic, auditory and working), executive function (planning, attention, mental flexibility) and visual-spatial processing were performed at baseline and after each treatment period. Isoflavone supplementation significantly improved spatial working memory (P=0.01), a test in which females consistently perform better than males. Compared with placebo supplementation, there were 18% fewer attempts (P=0.01), 23% fewer errors (P=0.02) and 17% less time (P=0.03) required to correctly identify the requisite information. Isoflavones did not affect auditory and episodic memory (Paired Associate Learning, Rey's Auditory Verbal Learning Task, Backward Digit Span and Letter-Number Sequencing), executive function (Trail Making and Initial Letter Fluency Task) or visual-spatial processing (Mental Rotation Task). Isoflavone supplementation in healthy males may enhance cognitive processes which appear dependent on oestrogen activation.