COMPARISON OF TUMOR PATHOLOGY WITH DURATION OF SURVIVAL OF NORTH-AMERICAN PATIENTS WITH HEPATOCELLULAR-CARCINOMA
COMPARISON OF TUMOR PATHOLOGY WITH DURATION OF SURVIVAL OF NORTH-AMERICAN PATIENTS WITH HEPATOCELLULAR-CARCINOMA
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DOI：
10.1002/1097-0142(19950815)76:4
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发表时间：
1995-08-15
期刊：
影响因子：
6.2
通讯作者：
ISHAK, KG
中科院分区：
文献类型：
--
作者：
NZEAKO, UC;GOODMAN, ZD;ISHAK, KG
背景几项关于肝细胞癌（HCC）预后和生存率的大型研究来自欧洲和亚洲，但只有少数来自北美，来自世界其他地区的生存统计数据可能不适用于北美人群，因为病因，人口统计学，文化，生活方式，目前的研究调查了北美HCC患者的生存经验和组织学相关性，并将结果与来自北美和其他地区的类似研究进行了比较。世界各地。在一年的时间内检查了1063名患者，符合本研究的入选标准。基于从诊断HCC之日起的生存期，将每名患者分为三个类别之一。对每种肿瘤进行组织学检查并根据世界卫生组织标准进行分类。从病例记录中获得患者诊断时的性别和年龄，采用适当的方法进行生存分析和比较。变量的相关性用卡方检验和随机化检验来检验。发现年龄、性别、肿瘤生长模式、Edmondson和Steiner核分级、有丝分裂指数、有无肿瘤巨细胞或门静脉浸润与患者生存时间具有统计学显著性（P < 0.05）的关系。发现女性性别、低核分级、低有丝分裂指数、诊断年龄小于50岁、无巨细胞，无门静脉侵犯。HCC的某些组织病理学特征可能有助于预测患者的生存率，从而有助于这些患者的经验性诊断。
Background. Several of the large studies addressing prognosis and survival from hepatocellular carcinoma (HCC) have been from Europe and Asia, but only a few have emanated from North America, Survival statistics from other parts of the world may not be applicable to the North American population because of etiologic, demographic, cultural, lifestyle, and intangible differences.The current study investigated the survival experience and histologic correlates of North American patients with HCC and compared findings with similar studies from North America and other parts of the world.Methods. One thousand sixty-three patients examined during a Ii-year period, met inclusion criteria for this study, Each patient was placed in one of three categories based on the duration of survival from date of diagnosis of HCC, Each tumor was examined histologically and classified according to World Health Organization criteria, Patient's sex and age at diagnosis were obtained from case records.Survival analyses and comparisons were performed using appropriate methods. Variables were tested for association using chi-square tests and randomization tests as appropriate.Results. Age, sex, tumor growth pattern, Edmondson and Steiner's nuclear grades, mitotic index, and presence or absence of tumor giant cells or portal venous invasion, were found to have statistically significant P < 0.05) relationships with the duration of patient survival, Significantly better survival was found to be associated with female sex, low nuclear grade, low mitotic index, age at diagnosis younger than 50 years, absence of giant cells, and absence of portal venous invasion.Conclusions. Certain histopathologic features of HCC may be useful for predicting patient survival and, thus, for empiric prognostication of these patients.