Alcohol and hepatitis C
Alcohol and hepatitis C
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DOI：
10.1159/000090176
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发表时间：
2005-01-01
影响因子：
2.3
通讯作者：
Morgan, TR
中科院分区：
文献类型：
--
作者：
Jamal, MM;Saadi, Z;Morgan, TR
背景/目标：酒精使用和丙型肝炎是肝损伤的主要危险因素，本文综述了目前对每个因素对肝脏疾病影响的理解。方法：检索Medline数据库中关于酒精、丙型肝炎和肝病的英文文献。还考虑了进一步适用文章的文献引用，我们的综述中纳入了最强有力的研究。结果：高达60%的丙型肝炎患者有饮酒史。在丙型肝炎患者中，长期饮酒超过5杯/天会增加肝纤维化的发生率，肝硬化，肝细胞癌的风险，并可能导致肝病死亡。许多研究进一步发现，即使是适量的酒精也会对丙型肝炎患者有害。患有晚期肝病的酗酒者中丙型肝炎的患病率高于无肝病的酗酒者。此外，近期饮酒会降低干扰素治疗的应答率。结论：丙型肝炎和酒精使用通常是肝脏疾病的共同危险因素，虽然它们的相互作用尚不清楚，但众所周知，大量饮酒会显著促进肝脏疾病的进展。版权所有（C）2005 S. Karger AG，巴塞尔。
Background/Aims: Alcohol use and hepatitis C are prominent risk factors for liver injury and this review offers the current understanding of each factor's effects on liver disease. Methods: A Medline database search was preformed for English articles with a focus on alcohol, hepatitis C and liver disease. Article citations were also considered for further applicable articles, and the strongest studies were included in our review. Results: Up to 60% of patients with hepatitis C have a past history of alcohol use. In patients with hepatitis C, chronic alcohol consumption of more than 5 drinks/ day increases the rate of liver fibrosis, risk for cirrhosis, hepatocellular carcinoma, and, possibly, death from liver disease. Numerous studies have further found that even moderate amounts of alcohol can be detrimental to hepatitis C patients. The prevalence of hepatitis C is higher in alcoholics with advanced liver disease than in alcoholics without liver disease. Also, recent alcohol use decreases the response rate to interferon treatment. Conclusions: Hepatitis C and alcohol use are often co-occurring risk factors for liver disease, and though their interaction is not clear, it is known that heavy drinking significantly promotes liver disease progression. Copyright (C) 2005 S. Karger AG, Basel.