Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials
Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials
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补充辅酶 Q10 对成人血脂的影响：随机对照试验的荟萃分析
DOI：
10.1210/clinem/dgac585
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Yan Yang
中科院分区：
文献类型：
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作者：
Zhihao Liu;Zezhong Tian;Dan Zhao;Ying Liang;Suming Dai;Meitong Liu;Shanshan Hou;Xiaoxi Dong;Zhaxinima;Yan Yang
抽象。上下文先前的荟萃分析表明，辅酶Q10（CoQ 10）对血脂的影响仍然存在争议。此外，没有荟萃分析探讨了辅酶Q10的最佳摄入量，以减轻成人的血脂谱。Objective.这项研究进行了一项荟萃分析，以确定辅酶Q10对血脂的影响，并评估其在成人中的剂量反应关系。方法.对数据库（Web of Science、PubMed/Medline、Embase和科克伦图书馆）进行系统检索，直至2022年8月10日。使用随机效应模型计算循环脂质谱变化的平均差异（MD）和95% CI。应用新的单阶段约束三次样条回归模型探索非线性剂量-效应关系。结果50项随机对照试验，共2794名参与者被纳入定性综合。汇总分析显示，辅酶Q10补充剂显著降低总胆固醇（TC）（MD −5.53 mg/dL; 95% CI −8.40，−2.66; I2 = 70%），低密度脂蛋白胆固醇（LDL-C）（MD −3.03 mg/dL; 95% CI −5.25，−0.81; I2 = 54%）和甘油三酯（TG）（MD −9.06 mg/dL; 95% CI −14.04，−4.08; I2 = 65%）和高密度脂蛋白胆固醇（HDL-C）升高（MD 0.83 mg/dL; 95% CI 0.01，1.65; I2 = 82%）。剂量-反应分析显示，辅酶Q10与TC呈反J型非线性关系，其中400-500 mg/d辅酶Q10显著降低TC（χ2 = 48.54，P0.01）。结论补充辅酶Q10可降低成年人的TC、LDL-C和TG水平，升高HDL-C水平，且400 ~ 500 mg/d剂量对TC的影响最大。
Abstract. Context. Previous meta-analyses have suggested that the effects of coenzyme Q10 (CoQ10) on lipid profiles remain debatable. Additionally, no meta-analysis has explored the optimal intake of CoQ10 for attenuating lipid profiles in adults.. Objective. This study conducted a meta-analysis to determine the effects of CoQ10 on lipid profiles and assess their dose–response relationships in adults.. Methods. Databases (Web of Science, PubMed/Medline, Embase, and the Cochrane Library) were systematically searched until August 10, 2022. The random effects model was used to calculate the mean differences (MDs) and 95% CI for changes in circulating lipid profiles. The novel single-stage restricted cubic spline regression model was applied to explore nonlinear dose–response relationships.. Results. Fifty randomized controlled trials with a total of 2794 participants were included in the qualitative synthesis. The pooled analysis revealed that CoQ10 supplementation significantly reduced total cholesterol (TC) (MD −5.53 mg/dL; 95% CI −8.40, −2.66; I2 = 70%), low-density lipoprotein cholesterol (LDL-C) (MD −3.03 mg/dL; 95% CI −5.25, −0.81; I2 = 54%), and triglycerides (TGs) (MD −9.06 mg/dL; 95% CI −14.04, −4.08; I2 = 65%) and increased high-density lipoprotein cholesterol (HDL-C) (MD 0.83 mg/dL; 95% CI 0.01, 1.65; I2 = 82%). The dose–response analysis showed an inverse J-shaped nonlinear pattern between CoQ10 supplementation and TC in which 400-500 mg/day CoQ10 largely reduced TC (χ2 = 48.54, P .01).. Conclusion. CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.