Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial
Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial
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DOI：
10.1111/j.1365-2265.2010.03816.x
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发表时间：
2010-10-01
影响因子：
3.2
通讯作者：
Goswami, Ravinder
中科院分区：
文献类型：
--
作者：
Gupta, Rajat;Sharma, Uma;Goswami, Ravinder
维生素D缺乏症在世界范围内普遍存在。补充维生素D对维生素D缺乏症老年人骨骼肌力量的影响是可变的。目的研究补充钙和胆钙化醇对青年人肌肉力量和能量代谢的影响（24男/16女，平均年龄（SD）31中心点5 +/- 5中心点0岁）维生素缺乏症D患者随机接受口服胆钙化醇或（60 000 IU D3/周，持续8周，随后60 000 IU/月，持续4个月），每天给予1 g元素钙或双重安慰剂，持续6个月。在基线和6个月后，对6分钟步行试验和31 P磁共振波谱的肌肉能量代谢进行评估。2个月和6个月分别为25个中心点4 +/-9中心点9，94个中心点5 +/-53中心点8和56个中心点0 +/-17中心点0 nm，和21个中心点1 +/-9中心点4，32个中心点8 +/-14中心点4和29个中心点7 +/-15中心点0 nm。补充组的握力增加了2个中心点4公斤（95% CI）。= 1个中心点2-3个中心点6）; 3个中心点的胃比目鱼肌强度0 Nm（95% C.I. = 0中心点1-5中心点9）和15中心点9 m的步行距离（95%CI = 6个中心点3-25个中心点5）。肌肉能量参数在6 months.ConclusionsSix个月的cholecalciferol和钙的补充结果增强骨骼肌的力量和物理性能，尽管没有改变肌肉能量参数。每月补充60 000 IU的胆钙化醇不能维持25（OH）D水平在足够的范围内。
P>ContextVitamin D deficiency is prevalent worldwide. Vitamin D supplementation has shown variable effect on skeletal muscle strength in the elderly with hypovitaminosis D. There is a paucity of similar data in young individuals.ObjectiveTo study the effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in young individuals.SubjectsForty healthy volunteers (24M/16F, mean age (SD) 31 center dot 5 +/- 5 center dot 0 year) with hypovitaminosis D were randomized to either oral cholecalciferol (60 000 IU D3/week for 8 weeks followed by 60 000 IU/month for 4 months) with 1 g of elemental calcium daily or dual placebos for 6 months.MeasurementsHandgrip and gastro-soleus dynamometry, pinch-grip strength, respiratory pressures, 6-min walk-test and muscle energy metabolism on 31P magnetic resonance spectroscopy were assessed at baseline and after 6 months.ResultsThe mean serum 25(OH)D in the supplemented and placebo groups at baseline, two and 6 months were 25 center dot 4 +/- 9 center dot 9, 94 center dot 5 +/- 53 center dot 8 and 56 center dot 0 +/- 17 center dot 0 nm, and 21 center dot 1 +/- 9 center dot 4, 32 center dot 8 +/- 14 center dot 4 and 29 center dot 7 +/- 15 center dot 0 nm, respectively. The supplemented group gained a handgrip strength of 2 center dot 4 kg (95% C.I. = 1 center dot 2-3 center dot 6); gastro-soleus strength of 3 center dot 0 Nm (95% C.I. = 0 center dot 1-5 center dot 9) and walking distance of 15 center dot 9 m (95% C.I. = 6 center dot 3-25 center dot 5) over the placebo group after adjustment for age, gender and respective baseline parameters. Muscle energy parameters were comparable at 6 months.ConclusionsSix months of cholecalciferol and calcium supplementation results in enhanced skeletal muscle strength and physical performance despite no change in muscle energy parameters. Cholecalciferol supplementation of 60 000 IU per month could not maintain 25(OH)D levels in the sufficient range.