Smoking is associated with first-ever incidence of mental disorders: a prospective population-based study
Smoking is associated with first-ever incidence of mental disorders: a prospective population-based study
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DOI：
10.1111/j.1360-0443.2007.01885.x
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发表时间：
2007-08-01
期刊：
影响因子：
6
通讯作者：
de Graaf, Ron
中科院分区：
文献类型：
--
作者：
Cuijpers, Pim;Smit, Filip;de Graaf, Ron
目标 众所周知，烟草使用与精神障碍有关。然而，烟草使用与精神障碍之间的关联尚未在基于人群的前瞻性研究中得到充分检验。目前的研究旨在检查吸烟是否与精神障碍的首次发生有关。设计、背景和参与者 我们进行了一项基于人群的前瞻性流行病学研究（荷兰心理健康调查和发病率研究：NEMESIS），其中对 18-64 岁成年人的代表性样本（n = 7076）进行了访谈，以确定是否存在广泛的精神障碍。我们在基线后 1 年（n = 5618；回应率为 79.4%）和 3 年（n = 4796；67.8%）重新采访了他们。测量 根据 DSM-III-R 标准，通过综合国际诊断访谈 (CIDI) 评估精神障碍的存在，该访谈由经过培训的非专业访谈员进行。通过询问受访者在过去一年是否吸烟以及吸了多少支烟来评估烟草使用情况。研究结果 吸烟但从未患过精神障碍的受试者患精神障碍的风险增加（P < 0.01），并且在纠正精神障碍的主要风险指标后，这一点仍然显着。结论 吸烟不仅与精神障碍的患病率有关，而且与精神障碍的首次发病率有关。需要更多的研究来研究因果路径。
Aims It is well established that tobacco use is associated with mental disorders. However, the association between tobacco use and mental disorders has not yet been examined sufficiently in prospective, population-based studies. The current study is aimed at examining whether smoking is associated with first-ever incidence of mental disorders. Design, setting and participants We conducted a prospective, population-based epidemiological study (the Netherlands Mental Health Survey and Incidence Study: NEMESIS) in which a representative sample of adults aged 18-64 years (n = 7076) were interviewed to establish the presence of a broad range of mental disorders. We re-interviewed them at 1 year (n = 5618; response 79.4%) and 3 years (n = 4796; 67.8%) after baseline. Measurements The presence of mental disorders was assessed according to DSM-III-R criteria with the Composite International Diagnostic Interview (CIDI), which was administered by trained lay interviewers. Tobacco use was assessed by asking respondents whether they had smoked in the past year, and how many cigarettes they smoked. Findings Subjects who smoked but never had a mental disorder in their life, had an increased risk of developing a mental disorder (P < 0.01), and this remained significant after correcting for major risk indicators of mental disorders. Conclusions Smoking is associated not only with the prevalence, but also with first-ever incidence of mental disorders. More research is needed to study the causal pathways.