Pericytes in Brain Injury and Repair After Ischemic Stroke.
Pericytes in Brain Injury and Repair After Ischemic Stroke.
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DOI：
10.1007/s12975-016-0504-4
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发表时间：
2017-04
影响因子：
6.9
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Cai W;Liu H;Zhao J;Chen LY;Chen J;Lu Z;Hu X
周细胞是神经血管单位(NVU)的功能成分。它们为NVU的其他组成部分提供支持，并维持血脑屏障(BBB)的正常生理功能。脑缺血再灌流可引起周细胞的病理改变。周细胞和其他NVU成分之间的密切解剖和功能相互作用在卒中病理的进展中起着关键作用。本文综述了正常脑内周细胞的生物学和功能，并讨论了它们在脑缺血/再灌注损伤和修复中的作用。由于缺血性卒中主要发生在老年人，我们还回顾了与年龄相关的周细胞变化，以及这些变化如何使老年人大脑易受缺血/再灌注损伤。针对缺血和再灌注后周细胞反应的策略可能为缺血性中风提供新的治疗方法。
Pericytes are functional components of the neurovascular unit (NVU). They provide support to other NVU components and maintain normal physiological functions of the blood-brain barrier (BBB). The brain ischemia and reperfusion result in pathological alterations in pericytes. The intimate anatomical and functional interactions between pericytes and other NVU components play pivotal roles in the progression of stroke pathology. In this review, we depict the biology and functions of pericytes in the normal brain and discuss their effects in brain injury and repair after ischemia/reperfusion. Since ischemic stroke occurs mostly in elderly people, we also review age-related changes in pericytes and how these changes predispose aged brains to ischemic/reperfusion injury. Strategies targeting pericytes responses after ischemia and reperfusion may provide new therapies for ischemic stroke.