alpha-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinoma.
alpha-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinoma.
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DOI：
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发表时间：
2007
影响因子：
2.5
通讯作者：
T. Setoyama;S. Natsugoe;H. Okumura;M. Matsumoto;Y. Uchikado;N. Yokomakura;S. Ishigami;T. Aikou
中科院分区：
文献类型：
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作者：
T. Setoyama;S. Natsugoe;H. Okumura;M. Matsumoto;Y. Uchikado;N. Yokomakura;S. Ishigami;T. Aikou
本研究的目的是根据在细胞粘附中起重要作用的E-cadherin和α-catenin的表达来分析食管鳞状细胞癌（ESCC）的临床病理变量。方法采用免疫组织化学方法检测205例食管鳞癌患者的E-cadherin和α-catenin。将表达结果分为两组：表达保留（+）和表达减少（-）。结果E-cadherin（-）和α-catenin（-）的检出率分别为52%和54%，两者之间存在显著相关性。对于E-cadherin和α-catenin，表达降低与肿瘤深度、淋巴结转移、分期、复发和预后显著相关。在E-cadherin（+）组中，α-catenin（+）和α-catenin（-）患者在肿瘤深度、淋巴结转移、分期、血行和淋巴道复发方面差异有统计学意义（P分别< 0.001、<0.001、<0.001、<0.001和=0.007）。根据E-cadherin和α-catenin的共表达，E-cadherin（+）和α-catenin（+）患者预后最好，E-cadherin（-）和α-catenin（-）患者预后最差。多因素分析显示，α-连环蛋白表达是一个独立的预后因素。结论检测E-cadherin，尤其是α-catenin的表达对预测食管鳞癌的淋巴结转移和临床预后有重要意义。
BACKGROUND AND OBJECTIVES The purpose of the present study was to analyze clinicopathologic variables in esophageal squamous cell carcinoma (ESCC) according to expression of E-cadherin and alpha-catenin which play an important role in cell adhesion. METHODS We immunohistochemically examined E-cadherin and alpha-catenin in 205 patients with ESCC. The expression results were classified into two groups: preserved expression (+) and reduced expression (-). RESULTS The incidence of E-cadherin (-) and alpha-catenin (-) was 52% and 54%, respectively and significantly related each other. For both E-cadherin and alpha-catenin, reduced expression was significantly related to tumor depth, nodal metastasis, stage, recurrence, and prognosis. In the E-cadherin (+) group, the alpha-catenin (+) and alpha-catenin (-) patients differed significantly in tumor depth, nodal metastasis, stage, hematogenous and lymphatic recurrences (P < 0.001, <0.001, <0.001, <0.001 and =0.007, respectively). According to coexpression of E-cadherin and alpha-catenin, the prognosis was best in patients with E-cadherin (+) and alpha-catenin (+), and worst in patients with E-cadherin (-) and alpha-catenin (-). Multivariate analysis revealed that alpha-catenin expression was an independent prognostic factor. CONCLUSIONS The examination of expression of E-cadherin and especially alpha-catenin is useful for predicting lymph node metastasis and clinical outcome of ESCC.