Arterial Transit Time Mapping Obtained by Pulsed Continuous 3D ASL Imaging with Multiple Post-Label Delay Acquisitions: Comparative Study with PET-CBF in Patients with Chronic Occlusive Cerebrovascular Disease.
Arterial Transit Time Mapping Obtained by Pulsed Continuous 3D ASL Imaging with Multiple Post-Label Delay Acquisitions: Comparative Study with PET-CBF in Patients with Chronic Occlusive Cerebrovascular Disease.
复制标题
通过多个标签后延迟获取的脉冲连续3D ASL成像获得的动脉传输时间映射：与PET-CBF的比较研究：慢性闭塞性脑血管疾病患者的比较研究。
DOI：
10.1371/journal.pone.0156005
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Okazawa H
中科院分区：
文献类型：
--
作者：
Tsujikawa T;Kimura H;Matsuda T;Fujiwara Y;Isozaki M;Kikuta K;Okazawa H
动脉自旋标记（ASL）是一种无创磁共振（MR）灌注评估技术，在慢性闭塞性脑血管病患者中测量绝对脑血流量（CBF）时，动脉传递时间（ATT）是最关键的。我们验证了闭塞性脑血管疾病患者的ASL- cbf和ASL- att图谱，这些图谱由脉冲连续ASL （pCASL）计算，具有多个标签后延迟获取。15例患者接受了包括pCASL在内的磁共振扫描和15o -水正电子发射断层扫描（PET）以获得PET- cbf。还获得了不同标签后延迟（1.0、1.5、2.0、2.5和3.0秒）的MR图像，用于ATT校正。延迟补偿采用了2室模型（2CM）的理论框架。根据提出的2CM计算了ASL-CBF和ASL-ATT，并讨论了对CBF值和ATT校正特性的影响。对大脑中动脉（MCA）区域的逐像素和感兴趣区域进行线性回归分析。ASL-CBF和PET-CBF在体素值（r = 0.74±0.08，斜率：0.87±0.22，截距：6.1±4.9）和患侧MCA区域比较（R2 = 0.67, y = 0.83x + 6.3）和对侧（R2 = 0.66, y = 0.74x + 6.3）上均具有显著相关性。患侧asl - ats明显长于对侧（分别为1.51±0.41秒和1.12±0.30秒，p <0.0005）。使用延迟补偿的pCASL测量CBF是可行的，即使在改变的血流动力学状态下也相当准确。
Arterial transit time (ATT) is most crucial for measuring absolute cerebral blood flow (CBF) by arterial spin labeling (ASL), a noninvasive magnetic resonance (MR) perfusion assessment technique, in patients with chronic occlusive cerebrovascular disease. We validated ASL-CBF and ASL-ATT maps calculated by pulsed continuous ASL (pCASL) with multiple post-label delay acquisitions in patients with occlusive cerebrovascular disease. Fifteen patients underwent MR scans, including pCASL, and positron emission tomography (PET) scans with 15O-water to obtain PET-CBF. MR acquisitions with different post-label delays (1.0, 1.5, 2.0, 2.5 and 3.0 sec) were also obtained for ATT correction. The theoretical framework of 2-compartmental model (2CM) was also used for the delay compensation. ASL-CBF and ASL-ATT were calculated based on the proposed 2CM, and the effect on the CBF values and the ATT correction characteristics were discussed. Linear regression analyses were performed both on pixel-by-pixel and region-of-interest bases in the middle cerebral artery (MCA) territory. There were significant correlations between ASL-CBF and PET-CBF both for voxel values (r = 0.74 ± 0.08, slope: 0.87 ± 0.22, intercept: 6.1 ± 4.9) and for the MCA territorial comparison in both affected (R2 = 0.67, y = 0.83x + 6.3) and contralateral sides (R2 = 0.66, y = 0.74x + 6.3). ASL-ATTs in the affected side were significantly longer than those in the contralateral side (1.51 ± 0.41 sec and 1.12 ± 0.30 sec, respectively, p <0.0005). CBF measurement using pCASL with delay compensation was feasible and fairly accurate even in altered hemodynamic states.