Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease
Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease
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DOI：
10.1016/j.cortex.2016.09.006
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发表时间：
2016-11-01
期刊：
影响因子：
3.6
通讯作者：
Bastin, Julien
中科院分区：
文献类型：
--
作者：
Benis, Damien;David, Olivier;Bastin, Julien
丘脑底核(STN)在动作抑制过程中起着关键作用，可能是在不适当的反应必须被迅速抑制时，对运动系统起到快速刹车的作用。然而，在运动抑制过程中涉及STN的机制仍然不清楚，特别是因为在人类中报道的这种结构中相对缺乏单细胞反应。在这项研究中，我们使用细胞外微电极记录，在帕金森病(PD)患者的脑深部刺激手术中，研究STN在停止信号任务中抑制控制的神经生理学相关性。我们发现有两个神经元亚群在运动执行(GO单位)或运动抑制(STOP单位)期间做出反应。在患者的运动反应之前，GO单位被选择性地激发，而当患者在抑制过程持续时间之前的潜伏期成功地阻止他们的移动时，停止单位被选择性地激发。这些结果为STN在目前的反应抑制模型中的假设作用提供了电生理学证据。(C)爱思唯尔有限公司出版的2016年。
The subthalamic nucleus (STN) plays a critical role during action inhibition, perhaps by acting like a fast brake on the motor system when inappropriate responses have to be rapidly suppressed. However, the mechanisms involving the STN during motor inhibition are still unclear, particularly because of a relative lack of single-cell responses reported in this structure in humans. In this study, we used extracellular microelectrode recordings during deep brain stimulation surgery in patients with Parkinson's disease (PD) to study STN neurophysiological correlates of inhibitory control during a stop signal task. We found two neuronal subpopulations responding either during motor execution (GO units) or during motor inhibition (STOP units). GO units fired selectively before patients' motor responses whereas STOP units fired selectively when patients successfully withheld their move at a latency preceding the duration of the inhibition process. These results provide electrophysiological evidence for the hypothesized role of the STN in current models of response inhibition. (C) 2016 Published by Elsevier Ltd.