The impact of comprehensive prevention of mother-to-child HIV transmission in Dehong prefecture, Yunnan province, 2005-2010: a hard-hit area by HIV in Southern China
The impact of comprehensive prevention of mother-to-child HIV transmission in Dehong prefecture, Yunnan province, 2005-2010: a hard-hit area by HIV in Southern China
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DOI：
10.1177/0956462413499010
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发表时间：
2014-03-01
影响因子：
1.4
通讯作者：
Hu, Yiyun
中科院分区：
文献类型：
--
作者：
Shan, Duo;Sun, Jiangping;Hu, Yiyun
中国的艾滋病毒/艾滋病负担不成比例地集中在云南省，其中德宏州孕妇艾滋病毒感染率2003年达到1.3%，这一比率表明艾滋病毒/艾滋病已普遍流行。自那时起，该高流行地区就广泛开展预防工作，以减少母婴传播 (MTCT)。这些加强的减少母婴传播的努力及其对母婴传播的影响还有待检验。我们描述了 2005 年至 2010 年该地区孕妇获得艾滋病毒筛查和抗逆转录病毒治疗 (ART) 的情况发生的变化，以及这一时期母婴传播的相应减少。 2005年至2010年间，德宏州每年进行艾滋病筛查的孕妇人数增加了一倍多。接受艾滋病毒筛查的孕妇比例从估计的 15-20% 上升至 99.8%，接受抗逆转录病毒治疗的艾滋病毒感染孕妇比例从 63% 上升至 99%。我们估计，在此期间，感染艾滋病毒的母亲所生的艾滋病毒儿童比例从 15.4% 下降到 7.2%。在该地区采取综合干预措施后，母婴传播的持续低水平令人鼓舞。过去十年来，全面的预防母婴传播努力，加上国家和地方政府在该领域的政策支持，似乎是有效的。
The burden of HIV/AIDS in China has been disproportionately concentrated in Yunnan Province, where in Dehong prefecture, the HIV prevalence rate among pregnant women reached 1.3% in 2003, a rate that is indicative of a generalized epidemic. Since then, there have been extensive efforts to expand prevention to reduce mother-to-child transmission (MTCT) in this high-prevalence region. These intensified MTCT reduction efforts and their impact on MTCT are yet to be examined. We described the changes in access to HIV screening and antiretroviral therapy (ART) among pregnant women from 2005 to 2010 in this region and the corresponding reduction in MTCT over this period. Between 2005 and 2010, the annual number of pregnant women screened for HIV in Dehong Prefecture more than doubled. The proportion of pregnant women screened for HIV rose from an estimated 15-20% to 99.8%, and the proportion of HIV-infected pregnant women receiving ART increased from 63% to 99%. We estimate that the proportion of children born with HIV to HIV-infected mothers decreased from 15.4% to 7.2% over this period. Sustained low-level MTCT following comprehensive interventions in this region is encouraging. Over the last decade, comprehensive PMTCT efforts, coupled with national and local government policy support in this area appear to be effective.