Computational and neurobiological mechanisms underlying cognitive flexibility
Computational and neurobiological mechanisms underlying cognitive flexibility
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DOI：
10.1073/pnas.0509550103
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发表时间：
2006-05-02
影响因子：
11.1
通讯作者：
Wagner, AD
中科院分区：
文献类型：
--
作者：
Badre, D;Wagner, AD
在多个任务之间切换的能力是灵活行为的核心。虽然任务之间的切换很容易完成，一个公认的后果任务切换（TS）是行为放缓。这种转换成本的来源和认知控制对其解决方案的贡献仍然存在很大争议。在这里，我们测试是否主动干扰所产生的内存的地方灵活的性能的基本限制，以及是否前额叶控制过程有助于克服这些限制。TS期间事件相关功能MRI指数神经反应。认知控制和干扰的贡献在理论上是明确的任务绩效的计算模型。模型估计两个层次的积极干预，“概念冲突”和“反应冲突”，产生不同的预防相关的配置文件。左腹外侧前额叶皮层激活的模型估计的概念冲突，分离的左下顶叶皮层，这是模型估计的反应冲突。这些计算告知神经措施指定检索的概念表示TS期间的冲突的来源，并建议左腹外侧前额叶皮层解决这一冲突，以促进灵活的性能。
The ability to switch between multiple tasks is central to flexible behavior. Although switching between tasks is readily accomplished, a well established consequence of task switching (TS) is behavioral slowing. The source of this switch cost and the contribution of cognitive control to its resolution remain highly controversial. Here, we tested whether proactive interference arising from memory places fundamental constraints on flexible performance, and whether prefrontal control processes contribute to overcoming these constraints. Event-related functional MRI indexed neural responses during TS. The contributions of cognitive control and interference were made theoretically explicit in a computational model of task performance. Model estimates of two levels of proactive interference, "conceptual conflict" and "response conflict," produced distinct preparation-related profiles. Left ventrolateral prefrontal cortical activation paralleled model estimates of conceptual conflict, dissociating from that in left inferior parietal cortex, which paralleled model estimates of response conflict. These computationally informed neural measures specify retrieved conceptual representations as a source of conflict during TS and suggest that left ventrolateral prefrontal cortex resolves this conflict to facilitate flexible performance.