Association of the 1031 MC4R allele with decreased body mass in 7937 participants of two population based surveys -: art. no. e21
Association of the 1031 MC4R allele with decreased body mass in 7937 participants of two population based surveys -: art. no. e21
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DOI：
10.1136/jmg.2004.027011
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发表时间：
2005-04-01
影响因子：
4
通讯作者：
Kronenberg, F
中科院分区：
文献类型：
--
作者：
Heid, IM;Vollmert, C;Kronenberg, F
背景：黑皮质素-4受体基因（MC 4 R）是黑皮质素能通路的一部分，控制能量稳态。在最近的荟萃分析中，MC 4 R V103 I（rs 2229616）多态性被证明与体重调节相关。尽管尚未检测到包含异亮氨酸的受体和野生型受体之间的功能差异，但14项病例对照研究的荟萃分析报告了与肥胖的轻度负相关性（比值比（OR）0.69，p = 0.03）。然而，在一个大规模的基于同质人群的研究中，仍然缺乏证据来评估肥胖定量指标的变化。方法：我们分析了两个白色人群的调查数据，这些调查采用相同的高质量研究方案，共7937名参与者。通过线性回归，我们发现0.52体重指数（BMI）单位的显着下降（95%置信区间（CI）20.02至21.03，p = 0.043）的杂合子rs 2229616 G/A基因型，这是在3.7%的参与者中观察到的携带者。Logistic回归显示MC 4 R变异与“高于平均体重”（BMI >=中位数BMI）呈显著负相关，OR为0.75（95%CI 0.59 - 0.95 p = 0.017）。我们比较肥胖（BMI >= 30 kg/m2，世界卫生组织1997年的结果）和非肥胖（BMI>= 30 kg/m2，世界卫生组织1997年的结果），
Background: The melanocortin-4-receptor gene (MC4R) is part of the melanocortinergic pathway that controls energy homeostasis. In a recent meta-analysis, the MC4R V103I (rs2229616) polymorphism was shown to be associated with body weight regulation. Although no functional differences between the isoleucine comprising receptor and the wild type receptor have been detected as yet, this meta-analysis of 14 case-control studies reported a mild negative association with obesity (odds ratio (OR) 0.69, p = 0.03). However, evidence in a large population based study in a homogeneous population and a significant estimate of the change in quantitative measures of obesity is still lacking.Methods: We analysed the data of two surveys of a white population with the same high quality study protocol, giving a total of 7937 participants.Results: By linear regression, we found a significant decrease of 0.52 body mass index (BMI) units (95% confidence interval (CI) 20.02 to 21.03, p = 0.043) for carriers of the heterozygote rs2229616G/A genotype, which was observed in 3.7% of the participants. Logistic regression yielded a significantly negative association of the MC4R variant with "above average weight" (BMI >= median BMI) yielding an OR of 0.75 (95% CI 0.59 to 0.95 p = 0.017). We obtained similar results comparing obese (BMI >= 30 kg/m(2), World Health Organization results for 1997) with non-obese (BMI