Role of Alternative Splicing in Regulating Host Response to Viral Infection.
Role of Alternative Splicing in Regulating Host Response to Viral Infection.
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DOI：
10.3390/cells10071720
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发表时间：
2021-07-08
期刊：
影响因子：
6
通讯作者：
Garcia-Blanco MA
中科院分区：
文献类型：
--
作者：
Liao KC;Garcia-Blanco MA
宿主基因转录调控在抵抗病毒感染的先天免疫中的重要性已被广泛认识。最近，转录后调节机制作为微调宿主免疫反应的一个额外和重要的调节层得到了重视。在这里，我们回顾了选择性剪接在病毒感染的先天免疫反应中的功能意义。我们描述了I型和III型干扰素途径的几个中心成分如何编码拼接的异构体来调节干扰素的激活和功能。此外，还讨论了剪接因子和调节剂在抗病毒免疫中的功能作用。最后，我们讨论了细胞死亡途径是如何通过选择性剪接来调节的，以及这种调节在宿主免疫和病毒感染中的潜在作用。总之，这些研究强调了RNA剪接在调节宿主-病毒相互作用中的重要性，并表明在下调抗病毒先天免疫方面发挥了作用；这可能是预防病理性炎症的关键。
The importance of transcriptional regulation of host genes in innate immunity against viral infection has been widely recognized. More recently, post-transcriptional regulatory mechanisms have gained appreciation as an additional and important layer of regulation to fine-tune host immune responses. Here, we review the functional significance of alternative splicing in innate immune responses to viral infection. We describe how several central components of the Type I and III interferon pathways encode spliced isoforms to regulate IFN activation and function. Additionally, the functional roles of splicing factors and modulators in antiviral immunity are discussed. Lastly, we discuss how cell death pathways are regulated by alternative splicing as well as the potential role of this regulation on host immunity and viral infection. Altogether, these studies highlight the importance of RNA splicing in regulating host–virus interactions and suggest a role in downregulating antiviral innate immunity; this may be critical to prevent pathological inflammation.
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