Etiology of asthma exacerbations
Etiology of asthma exacerbations
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DOI：
10.1016/j.jaci.2008.08.017
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发表时间：
2008-10-01
影响因子：
14.2
通讯作者：
Johnston, Sebastian L.
中科院分区：
文献类型：
--
作者：
Sykes, Annemarie;Johnston, Sebastian L.
哮喘急性发作是常见的，与哮喘相关的主要发病率、死亡率和医疗费用与急性发作有关。大多数与病毒感染有关，尽管在确定病毒诱导的哮喘急性发作的机制方面取得了进展，但仍有许多需要了解的。与其他环境暴露一样，过敏原暴露会导致某些病情加重，并可能参与病毒诱导的病情加重。非典型细菌感染在急性加重中的作用也越来越被认识到。急性发作的特征是气道炎症，其类型可以根据其主要是感染性还是过敏性而不同。对炎症通路的进一步了解可能会导致识别新的预防或治疗策略的发展目标。
Asthma exacerbations are common, and the major morbidity, mortality, and health care costs associated with asthma are related to exacerbations. The majority are related to viral infection, and although progress has been made in identifying the mechanisms of virus-induced asthma exacerbations, there is still much to be learned. Allergen exposure causes some exacerbations and can participate in virus-induced exacerbations, as can other environmental exposures. A role for atypical bacterial infection in exacerbations is also increasingly recognized. Exacerbations are characterized by airway inflammation, which can differ in type depending on whether it is primarily infective or allergic in origin. An increased understanding of the inflammatory pathways might lead to identification of targets for the development of novel prevention or treatment strategies.