MATLYSTATINS, NEW INHIBITORS OF TYPEIV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .2. BIOLOGICAL-ACTIVITIES
MATLYSTATINS, NEW INHIBITORS OF TYPEIV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .2. BIOLOGICAL-ACTIVITIES
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DOI：
10.7164/antibiotics.45.1733
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发表时间：
1992-11-01
影响因子：
3.3
通讯作者：
SHIMADA, K
中科院分区：
文献类型：
--
作者：
TANZAWA, K;ISHII, M;SHIMADA, K
matlystatins的主要成分matlystatins A抑制92 kDa和72 kDa IV型胶原酶，IC 50值分别为0.3 μ M和0.56 μ M，而抑制嗜热菌蛋白酶和氨肽酶M需要7- 11倍的浓度。这种抑制作用是可逆的，与明胶具有竞争性。它抑制人纤维肉瘤HT 1080对基底膜Matrigel的侵袭，呈剂量依赖性，IC 50值为21.6 μ M。
Matlystatin A, the main component of matlystatins, inhibits 92kDa and 72kDa typeIV collagenases with IC50 values of 0.3 muM and 0.56 muM, respectively, while 7- to 11-fold greater concentrations are required to inhibit thermolysin and aminopeptidase M. The inhibition is reversible and competitive with respect to gelatin. It inhibits the invasion of basement membrane Matrigel by human fibrosarcoma HT1080 dose-dependently with an IC50 value of 21.6 muM.