Family Communication of BRCA1/2 Results and Family Uptake of BRCA1/2 Testing in a Diverse Population of BRCA1/2 Carriers
Family Communication of BRCA1/2 Results and Family Uptake of BRCA1/2 Testing in a Diverse Population of BRCA1/2 Carriers
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DOI：
10.1007/s10897-013-9592-4
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发表时间：
2013-10-01
影响因子：
1.9
通讯作者：
Kaplan, Celia
中科院分区：
文献类型：
--
作者：
Fehniger, Julia;Lin, Feng;Kaplan, Celia
以前的研究检查BRCA 1/2结果与亲属的沟通和BRCA 1/2检测的家庭吸收，从主要是白色，高SES队列中抽样，仅从三级保健中心确定。没有研究集中在不同BRCA 1/2携带者的亲属之间的家庭沟通和测试。我们对一家公立医院和一家三级癌症中心确定的73名BRCA 1/2携带者进行了结构化访谈。我们询问参与者是否每个一级和二级亲属都知道他们的BRCA 1/2结果，以及每个亲属是否都进行了测试。广义估计方程确定率和家庭沟通和测试的预测。参与者向606名合格亲属中的73%和514名合格亲属中的31%透露了他们的测试结果。来自公立医院和三级癌症中心的参与者亲属的沟通和检测率相似。医院网站是不是一个显着的预测结果披露或相对吸收的测试。非裔美国人和亚洲/太平洋岛民的参与者显着不太可能透露他们的结果给他们的亲属;非裔美国人参与者的亲属显着不太可能测试。解决这些差异将需要进一步研究促进家庭沟通的最佳方法，并为种族和社会经济多样化的BRCA 1/2突变携带者的高危亲属提供咨询。
Previous studies examining communication of BRCA1/2 results with relatives and family uptake of BRCA1/2 testing have sampled from predominantly white, high SES cohorts ascertained solely from tertiary care centers. No studies have focused on family communication and testing among relatives of diverse BRCA1/2 carriers. We conducted structured interviews with 73 BRCA1/2 carriers identified at a public hospital and a tertiary cancer center. We asked participants if each first- and second-degree relative was aware of their BRCA1/2 results and whether or not each relative had tested. Generalized estimating equations identified rates and predictors of family communication and testing. Participants disclosed their test results to 73 % of 606 eligible relatives and 31 % of 514 eligible relatives tested. Communication and testing rates were similar for relatives of participants from the public hospital and the tertiary cancer center. Hospital site was not a significant predictor of either result disclosure or relative uptake of testing. African American and Asian/Pacific Islander participants were significantly less likely to disclose their results to their relatives; relatives of African American participants were significantly less likely to test. Addressing these disparities will require further research into the best ways to facilitate family communication and counsel at-risk relatives of racially and socioeconomically diverse BRCA1/2 mutation carriers.