New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases.
New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases.
复制标题
DOI：
10.3389/fphar.2023.1097835
复制
发表时间：
2023
影响因子：
5.6
通讯作者：
Hu, Yiyang
中科院分区：
文献类型：
--
作者：
Li, Xiaojing;Liu, Qiaohong;Pan, Yuqing;Chen, Si;Zhao, Yu;Hu, Yiyang
肥胖及相关代谢性疾病的发病率在全球范围内呈上升趋势，对人类健康造成不利影响。膳食脂肪，尤其是甘油三酯是身体的重要能量来源，肠道通过一系列有序而复杂的步骤吸收脂肪。长期的高脂肪饮食会导致肠道功能障碍，引发肥胖和代谢紊乱。因此，调节饮食中甘油三酯的吸收是一种很有前途的治疗策略。在这篇综述中，我们将讨论饮食中甘油三酯的水解、脂肪酸摄取、甘油三酯的再合成、乳糜粒的组装、运输和肠道上皮细胞的分泌过程的不同方面，以及这一过程中可能影响饮食脂肪诱导的肥胖和代谢性疾病的潜在靶点。我们还提到了在调节膳食脂肪吸收靶点方面可能存在的缺陷和不足，以更好地了解它们作为药物治疗肥胖症和相关代谢紊乱的可行性。
The incidence of obesity and associated metabolic diseases is increasing globally, adversely affecting human health. Dietary fats, especially triglycerides, are an important source of energy for the body, and the intestine absorbs lipids through a series of orderly and complex steps. A long-term high-fat diet leads to intestinal dysfunction, inducing obesity and metabolic disorders. Therefore, regulating dietary triglycerides absorption is a promising therapeutic strategy. In this review, we will discuss diverse aspects of the dietary triglycerides hydrolysis, fatty acid uptake, triglycerides resynthesis, chylomicron assembly, trafficking, and secretion processes in intestinal epithelial cells, as well as potential targets in this process that may influence dietary fat-induced obesity and metabolic diseases. We also mention the possible shortcomings and deficiencies in modulating dietary lipid absorption targets to provide a better understanding of their administrability as drugs in obesity and related metabolic disorders.
登录
查看更多内容
影响因子：
3.7
作者：
Chon SH;Douglass JD;Zhou YX;Malik N;Dixon JL;Brinker A;Quadro L;Storch J
通讯作者：
Storch J
影响因子：
15.9
作者：
BAIER, LJ;SACCHETTINI, JC;PROCHAZKA, M
通讯作者：
PROCHAZKA, M
影响因子：
6.5
作者：
Ables GP;Yang KJ;Vogel S;Hernandez-Ono A;Yu S;Yuen JJ;Birtles S;Buckett LK;Turnbull AV;Goldberg IJ;Blaner WS;Huang LS;Ginsberg HN
通讯作者：
Ginsberg HN
DOI：
10.1016/s1388-1981(99)00200-0
发表时间：
2000-01-31
影响因子：
4.8
作者：
Alpers, DH;Bass, NM;DeSchryver-Kecskemeti, K
通讯作者：
DeSchryver-Kecskemeti, K
影响因子：
3.5
作者：
Al-Thihli, Khalid;Afting, Cassian;Al-Maawali, Almundher
通讯作者：
Al-Maawali, Almundher