MHC-Based Mate Choice in Wild Golden Snub-Nosed Monkeys.
MHC-Based Mate Choice in Wild Golden Snub-Nosed Monkeys.
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野生金丝猴基于 MHC 的配偶选择
DOI：
10.3389/fgene.2020.609414
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发表时间：
2020
影响因子：
3.7
通讯作者：
Li BG
中科院分区：
文献类型：
--
作者：
Zhang BY;Hu HY;Song CM;Huang K;Dunn DW;Yang X;Wang XW;Zhao HT;Wang CL;Zhang P;Li BG
主要组织相容性复合体（MHC）基因是脊椎动物免疫系统的重要组成部分，在许多物种的配偶选择中起着重要作用。然而，目前还不清楚非人灵长类动物的雌性配偶选择是否基于特定的功能基因和/或全基因组基因。金丝猴生活在一个多层次的社会中，由多个一雄多雌的单位组成。虽然成年雌性倾向于主要与一个成年雄性交往，但雌性经常与其他雄性进行额外配对交配，导致很高比例的后代由额外配对的雄性所生。我们研究了适应性MHC基因和中性微卫星对野生红腹滨鹬雌性择偶的影响。roxellana种群我们使用两个MHC II类基因座（Rhro-DQA 1和Rhro-DQB 1）和20个来自3年数据的微卫星对54个亲子三联体进行测序。我们发现，子代的父系与男性MHC组成非随机相关，而与微卫星基因型无关。我们的研究表明，所有婴儿的父亲有显着较小的方差的几个估计的遗传相似性的母亲相比，随机男性在两个MHC基因座。此外，这些父亲的MHC多样性显着高于随机男性。我们还发现了基于特定等位基因的选择的支持;与随机雄性相比，Rhro-DQA 1_05和Rhro-DQB 1_08在OMU（一个雄性单位）雄性和后代的遗传父亲中更常见。这项研究提供了新的证据，为女性的MHC-中间相异度（而不是最大的MHC相异度）的择偶，并强调了将多个MHC基因座和社会结构的重要性，在非人灵长类动物的MHC为基础的择偶研究。
The genes of the major histocompatibility complex (MHC) are an important component of the vertebrate immune system and play a significant role in mate choice in many species. However, it remains unclear whether female mate choice in non-human primates is based on specific functional genes and/or genome-wide genes. The golden snub-nosed monkey (Rhinopithecus roxellana) lives in a multilevel society, which consists of several polygynous one-male-several-female units. Although adult females tend to mainly socialize with one adult male, females often initiate extra-pair copulations with other males resulting in a high proportion of offspring being fathered by extra-pair males. We investigated the effects of adaptive MHC genes and neutral microsatellites on female mate choice in a wild R. roxellana population. We sequenced 54 parent-offspring triads using two MHC class II loci (Rhro-DQA1 and Rhro-DQB1) and 20 microsatellites from 3 years of data. We found that the paternities of offspring were non-randomly associated with male MHC compositions not microsatellite genotypes. Our study showed that the fathers of all infants had significantly less variance for several estimates of genetic similarity to the mothers compared with random males at both MHC loci. Additionally, the MHC diversity of these fathers was significantly higher than random males. We also found support for choice based on specific alleles; compared with random males, Rhro-DQA1∗ 05 and Rhro-DQB1∗ 08 were more common in both the OMU (one-male unit) males and the genetic fathers of offspring. This study provides new evidence for female mate choice for MHC-intermediate dissimilarity (rather than maximal MHC dissimilarity) and highlights the importance of incorporating multiple MHC loci and social structure into studies of MHC-based mate choice in non-human primates.