Recent advances in cutaneous HPV infection
Recent advances in cutaneous HPV infection
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DOI：
10.1111/1346-8138.16697
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发表时间：
2023-01
期刊：
影响因子：
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通讯作者：
A. Shimizu;R. Yamaguchi;Y. Kuriyama
中科院分区：
文献类型：
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作者：
A. Shimizu;R. Yamaguchi;Y. Kuriyama
迄今为止，已经报道了200多种类型的人乳头瘤病毒（HPV），并且与各种皮肤病有关。在皮肤病中，病毒性疣是最常见的报告与HPV有关。疣状表皮发育不良（EV）包括三种类型：典型EV是具有TMC 6/TMC 8基因突变的常染色体隐性遗传病，非典型EV是由于导致免疫缺陷的各种基因突变而发生的，获得性EV是由于获得性免疫缺陷而发生的。全身性疣状病与EV的不同之处在于它涉及许多疣状结节（主要在肢体上），组织病理学上没有EV中观察到的蓝色细胞，以及皮肤α-HPV和β-HPV的感染。HPV诱导的皮肤恶性肿瘤包括EV患者、器官移植受者和健康个体中由β-HPV（尤其是HPV 5型和8型）引起的鳞状细胞癌（SCC），以及由粘膜高危型HPV感染引起的外阴和指甲单位SCC。β-HPV的致癌作用与阳光有关。粘液瘤高危型HPV相关癌也可能通过性传播。我们专注于指甲的Bowen病，这是我们长期研究的主题，最近在皮肤科领域脱颖而出。
More than 200 types of human papillomavirus (HPV) have been reported to date and have been associated with various dermatological diseases. Among dermatological diseases, viral verrucae are the most commonly reported to be associated with HPV. Epidermodysplasia verruciformis (EV) consists of three types: typical EV is an autosomal recessive genetic disorder with TMC6/TMC8 gene mutations, atypical EV develops due to various gene mutations that cause immunodeficiency, and acquired EV develops due to acquired immunodeficiency. Generalized verrucosis differs from EV in that it involves numerous verrucous nodules (mainly on the limbs), histopathologically no blue cells as seen in EV, and infection with cutaneous α‐HPVs as well as β‐HPVs. HPV‐induced skin malignancies include squamous cell carcinoma (SCC) caused by β‐HPV (especially HPV types 5 and 8) in EV patients, organ transplant recipients, and healthy individuals, and SCC of the vulva and nail unit caused by mucosal high‐risk HPV infection. Carcinogenesis of β‐HPV is associated with sunlight. Mucosal high‐risk HPV‐associated carcinomas may also be sexually transmitted. We focused on Bowen's disease of the nail, which has been the subject of our research for a long time and has recently come to the fore in the field of dermatology.