The relationship of bone and blood lead to hypertension - The normative aging study
The relationship of bone and blood lead to hypertension - The normative aging study
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DOI：
10.1001/jama.275.15.1171
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发表时间：
1996-04-17
影响因子：
120.7
通讯作者：
Rotnitzky, A
中科院分区：
文献类型：
--
作者：
Hu, H;Aro, A;Rotnitzky, A
目的：-检验这样一种假设，即长期的铅积累(与反映最近铅暴露的血液中的铅水平相反)与患高血压的几率增加有关。设计-退伍军人管理局(现为退伍军人事务部)标准老龄化研究的参与者的病例对照研究，这是一项对男性参与者的30年纵向研究。-在1991年8月至1994年12月期间观察的1171名活跃受试者中，590人(50%)参与了这项调查，并掌握了所有感兴趣变量的数据。主要结果指标：高血压被定义为在检查期间每天服用药物治疗高血压或收缩压高于160毫米汞或舒张压高于96毫米汞的患者。用Kx射线荧光仪(KXRF)活体测量胫骨(代表皮质骨)和膝盖骨(代表小梁骨)中的铅水平。采用石墨炉原子吸收光谱仪测定血铅水平。结果：血铅水平较低，<0.05~1.35Mol/L(P<0.05)。
Objective.-To test the hypothesis that long-term lead accumulation, as reflected by levels of lead in bone (as opposed to blood, which reflects recent lead exposure), is associated with an increased odds of developing hypertension.Design.-Case-control study of participants in the Veterans Administration (now Department of Veterans Affairs) Normative Aging Study, a 30-year longitudinal study of men.Participants.-Of 1171 active subjects who were seen between August 1991 and December 1994, 590 (50%) participated in this investigation and had data on all variables of interest.Main Outcome Measures.-Hypertension was defined as taking daily medication for the treatment of hypertension or systolic blood pressure higher than 160 mm Hg or diastolic blood pressure of 96 mm Hg or higher during the time of examination. Levels of lead in the tibia (representing cortical bone) and the patella (representing trabecular bone) were measured in vivo with a K x-ray fluorescence (KXRF) instrument. Levels of lead in blood were measured by graphite furnace atomic absorption spectroscopy.Results.-Blood lead levels were low, ranging from less than 0.05 to 1.35 mu mol/L (