High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study.
High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study.
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农业健康研究中农药施用者的高农药暴露事件和中枢神经系统功能。
DOI：
10.1007/s00420-011-0694-8
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发表时间：
2012
影响因子：
3
通讯作者：
Hoppin,JaneA
中科院分区：
文献类型：
--
作者：
Starks,SarahE;Gerr,Fred;Kamel,Freya;Lynch,CharlesF;Alavanja,MichaelC;Sandler,DaleP;Hoppin,JaneA
虽然急性农药中毒可能与持续的中枢神经系统（CNS）不良反应有关，但对一个或多个偶发性和异常高农药暴露事件（HPEE）的影响知之甚少，这些事件通常不会导致急性中毒。这项调查的目的是检查在参加农业健康研究（AHS）的有执照的农药施用者中曾经具有HPEE和CNS功能之间的关联。方法在2006-2008年，693名没有医生诊断的农药中毒史的男性参与者完成了9项神经行为测试，以评估记忆、运动速度、持续注意力、言语学习、视觉扫描和处理。从以前的AHS访谈中获得了有关HPEE和农药中毒的信息。曾经有一个HPEE和神经行为的结果之间的关联进行了估计与线性回归控制年龄和特定的协变量。ResultsA的历史上曾经有一个HPEE的156（23%）的参与者。在曾经进行过HPEE和九项神经行为测试中的两项之间观察到了不良关联。在视觉扫描和处理（数字符号）测试中，曾经有过HPEE的参与者比没有HPEE的参与者慢4.2秒（95% CI：-7.27，-1.11），相当于该人群中3.9岁的影响。在视觉扫描和运动速度测试（序列A）中，曾经有过HPEE的参与者比没有HPEE的参与者慢2.5秒（95% CI：-4.53，-0.41），相当于3.9岁的影响。没有显着的协会之间观察到参与者谁曾经有一个HPEE和其余的neurobiological tests.ConclusionsOne或多个HPEE可能会导致独立的诊断农药中毒的中枢神经系统不良后果。
PurposeWhile acute pesticide poisoning can be associated with persistent adverse central nervous system (CNS) effects, little is known about the effect of one or more episodic and unusually high pesticide exposure events (HPEE) that typically do not result in acute poisoning. The objective of this investigation was to examine the association between ever having an HPEE and CNS function among licensed pesticide applicators enrolled in the Agricultural Health Study (AHS).MethodsIn 2006–2008, 693 male participants with no history of a physician-diagnosed pesticide poisoning completed nine neurobehavioral tests to assess memory, motor speed, sustained attention, verbal learning, and visual scanning and processing. Information on ever having an HPEE and pesticide poisonings was obtained from previous AHS interviews. Associations between ever having an HPEE and neurobehavioral outcomes were estimated with linear regression controlling for age and outcome-specific covariates.ResultsA history of ever having an HPEE was reported by 156 (23%) participants. Adverse associations were observed between ever having an HPEE and two of the nine neurobehavioral tests. On a test of visual scanning and processing (Digit-Symbol), participants who ever had an HPEE were 4.2 s slower (95% CI: −7.27, −1.11) than those without an HPEE, equivalent to the effect of 3.9 years of age in this population. On a test of visual scanning and motor speed (Sequences A), participants who ever had an HPEE were 2.5 s slower (95% CI: −4.53, −0.41) than those without an HPEE, equivalent to the effect of 3.9 years of age. No significant associations were observed between participants who ever had an HPEE and the remaining neurobehavioral tests.ConclusionsOne or more HPEE may contribute to adverse CNS outcomes independent of diagnosed pesticide poisoning.