Drug-resin drug interactions in patients with delayed gastric emptying: What is optimal time window for drug administration?
Drug-resin drug interactions in patients with delayed gastric emptying: What is optimal time window for drug administration?
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DOI：
10.1111/nmo.12823
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发表时间：
2016-08-01
影响因子：
3.5
通讯作者：
Camilleri, M.
中科院分区：
文献类型：
--
作者：
Camilleri, M.
大多数药物相互作用涉及药物代谢途径的重叠或竞争。然而，有一些药物，通常是树脂，其功能是将有害物质如胆汁酸或钾结合在消化道内。本文的目的是审查胃的功能和排空不同的食物形式或配方的动力学，以提出建议的时间给药，以避免胃内药物相互作用。基于液体营养物和均质化固体的排空曲线和动力学，预计树脂药物和另一种“目标”药物给药之间的3小时窗口将允许80%的药物具有粒径
Most drug-drug interactions involve overlap or competition in drug metabolic pathways. However, there are medications, typically resins, whose function is to bind injurious substances such as bile acids or potassium within the digestive tract. The objective of this article is to review the functions of the stomach and the kinetics of emptying of different food forms or formulations to make recommendations on timing of medication administration in order to avoid intragastric drug interactions. Based on the profiles and kinetics of emptying of liquid nutrients and homogenized solids, a window of 3 h between administration of a resin drug and another 'target' medication would be expected to allow a median of 80% of medications with particle size