Pulsatile brain movement and associated hydrodynamics studied by magnetic resonance phase imaging
Pulsatile brain movement and associated hydrodynamics studied by magnetic resonance phase imaging
复制标题
通过磁共振相位成像研究脉动脑运动和相关流体动力学
作者：
D. Greitz;R. Wirestam;A. Franck;B. Nordell;C. Thomsen;F. Ståhlberg
摘要使用门控自旋回波 MRI 序列研究了 15 名健康志愿者的轴向、矢状和冠状平面的脑组织运动。所有运动都具有不同于灌注和扩散的特征。最高速度出现在收缩期的基底神经节（最大 1.0 毫米/秒）和脑干（最大 1.5 毫米/秒）。基底神经节的运动方向为尾部、内侧和后部，脑桥的运动方向为尾部前部。尾部和前部运动朝枕骨大孔和中线方向增加。由此产生的运动以漏斗状的方式发生，就好像大脑被脊髓拉动一样。这可以通过脑和脑脊液（CSF）通过小脑幕切迹和枕骨大孔排出来解释。根据 Monro-Kellie 学说，颅内容量被假定为始终恒定。颅内动力学可以被视为四个主要成分的空间需求之间的相互作用：动脉血、毛细血管血（脑容量）、静脉血和脑脊液。通过将门罗-凯利学说应用于心动周期的每个时刻，可以表征这些成分，并区分动脉和大脑的扩张。动脉扩张导致大脑重塑，使其能够发挥活塞般的作用。动脉扩张通过将脑脊液排入椎管为大脑的扩张创造了先决条件。大脑的扩张反过来又导致脑室系统的压缩，从而导致脑脊液的脑室内流动。
SummaryBrain tissue movements were studied in axial, sagittal and coronal planes in 15 healthy volunteers, using a gated spin echo MRI sequence. All movements had characteristics different from those of perfusion and diffusion. The highest velocities occurred during systole in the basal ganglia (maximum 1.0 mm/s) and brain stem (maximum 1.5 mm/s). The movements were directed caudally, medially and posteriorly in the basal ganglia, and caudally-anteriorly in the pons. Caudad and anterior motion increased towards the foramen magnum and towards the midline. The resultant movement occurred in a funnelshaped fashion as if the brain were pulled by the spinal cord. This may be explained by venting of brain and cerebrospinal fluid (CSF) through the tentorial notch and foramen magnum. The intracranial volume is assumed to be always constant by the Monro-Kellie doctrine. The intracranial dynamics can be viewed as an interplay between the spatial requirements of four main components: arterial blood, capillary blood (brain volume), venous blood and CSF. These components could be characterized, and the expansion of the arteries and the brain differentiated, by applying the Monro-Kellie doctrine to every moment of the cardiac cycle. The arterial expansion causes a remoulding of the brain that enables its piston-like action. The arterial expansion creates the prerequisites for the expansion of the brain by venting CSF to the spinal canal. The expansion of the brain is, in turn, responsible for compression of the ventricular system and hence for the intraventricular flow of CSF.
流体剪切和自旋回波图像。
影响因子：
3.3
作者：
Kuethe,DO;Herfkens,RJ
通讯作者：
Herfkens,RJ