Incidence of perioperative anaphylaxis in 2021 in Japan: Survey of 34 hospitals of Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc
Incidence of perioperative anaphylaxis in 2021 in Japan: Survey of 34 hospitals of Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc
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2021年日本围手术期过敏反应发生率：对社会福利组织济生会帝国礼品基金会旗下34家医院的调查
DOI：
10.1101/2022.11.08.22282102
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Mogi Masaki
中科院分区：
文献类型：
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作者：
Suzuki Yasuyuki;Liu Shuang;Yamashita Natsumi;Yamaguchi Naohito;Takasaki Yasushi;Yorozuya Toshihiro;Mogi Masaki
围手术期过敏反应（POA）是一种发生率低、危险因素多样的严重并发症。其低发病率使得详细调查POA具有挑战性。最近在日本进行的大规模调查集中在使用嗜碱性粒细胞活化试验确定致病因子。只有能够为该测试发送样本的机构（如大学医院）才参与，这可能会引入偏倚。我们主要调查了日本各地的二级医院（如Saiseikai医院）的POA发病率。我们的目标是收集2021年的数据。35家机构回答了问题（补充1、2）;我们排除了1家报告无手术的机构。总共进行了70，523次手术，其中7例诊断为POA。3例采用皮肤试验诊断，1例采用组胺和类胰蛋白酶定量诊断。在3例病例中，诊断基于药物使用后至POA发作的时间。多项检查对确保患者安全至关重要。然而，在这次调查中，没有医院进行体外测试来确定原因。这是主要的局限性，但是，由于许多医院没有实验室，我们认为，这项研究，重点是二级保健机构，有助于文献显着介绍临床实践中的现状。
Perioperative anaphylaxis (POA) is a severe complication with a low incidence and diverse risk factors. Its low incidence makes a detailed survey of POA challenging. Recent large-scale surveys in Japan have focused on identifying the causative agents using the basophil activation test. Only facilities, such as university hospitals, that can dispatch samples for this test participate, which may introduce bias. We surveyed the incidence of POA primarily in secondary hospitals, such as the Saiseikai hospitals, throughout Japan.We targeted data collection for the year 2021. Thirty-five facilities answered (Supplementary 1, 2); we excluded 1 reporting no surgeries. In total, 70,523 surgeries were performed, with POA diagnosed in 7 cases. For diagnosis, the skin test was used in 3 cases and quantification of histamine and tryptase in 1 case. In 3 cases, diagnosis was based on the time to onset of POA after drug use. Multiple tests are important to ensure patient safety. However, in this survey, no hospital performed in vitro tests to identify the cause. This is major limitation, however, as many hospitals do not have experimental laboratories, we believe that this study, which focuses on secondary care institutions, contributes to the literature significantly by presenting the current situation in clinical practice.