Venous leg ulcers - the search for a prognostic indicator.
Venous leg ulcers - the search for a prognostic indicator.
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DOI：
10.1111/j.1742-481x.2007.00335.x
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发表时间：
2007-06-01
影响因子：
3.1
通讯作者：
Harding, Keith G
中科院分区：
文献类型：
--
作者：
Moore, Keith;Huddleston, Elizabeth;Harding, Keith G
慢性伤口中的细胞功能紊乱会产生许多参数，可以通过测量来区分愈合和非愈合状态。理论上，这些可以形成伤口评估系统的基础，以确定疾病的严重程度和对治疗的反应。在对下肢静脉性溃疡的组织、伤口渗出液和微生物学研究的回顾中，我们发现了许多与愈合状态相关的参数。这些包括细胞因子、蛋白酶及其抑制剂、衰老标记物、氧化应激标记物和由培养定义的微生物状态。其中一些，如伤口渗出液中的蛋白酶水平，被认为是愈合状态的预后指标，还有更多的可能被认为是纳入伤口评估系统的潜在标志物。然而，没有公开的数据证实已知的伤口成分可以准确地反映单个患者的伤口进展。与其进一步表征已知伤口生物标志物的表达，不如开发一种准确客观的慢性伤口预后预测测试，这需要识别出与愈合状态协调变化的新分子的适当组合。
Disordered cell function within chronic wounds generates many parameters that can be measured to differentiate between healing and non healing status. Theoretically, these may form the basis of a wound assessment system to define disease severity and response to treatment. In a review of tissue, wound exudate and microbiology studies of venous leg ulcers, we identify many such parameters that are associated with healing status. These include cytokines, proteases and their inhibitors, senescence markers, oxidative stress markers and microbiological status defined by culture. Some of these, such as protease level in wound exudate, have been proposed as prognostic indicators of healing status and many more could be considered potential markers to incorporate into a wound assessment system. However, no published data are available that validate known wound components to accurately reflect wound progression on a single patient basis. Rather than further characterisation of the expression of known wound biomarkers, the development of an accurate and objective test for prediction of chronic wound outcome requires identification of an appropriate combination of novel molecules that vary coordinately with healing status.