PATHOLOGY OF SALMONELLA COLITIS
PATHOLOGY OF SALMONELLA COLITIS
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DOI：
10.1097/00000478-197912000-00001
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发表时间：
1979-01-01
影响因子：
5.6
通讯作者：
SLAVUTIN, LJ
中科院分区：
文献类型：
--
作者：
MCGOVERN, VJ;SLAVUTIN, LJ
沙门氏菌性结肠炎8例。在7例患者中，临床和放射学上类似溃疡性结肠炎。第8例患者的沙门氏菌感染与迄今未发现的溃疡性结肠炎重叠。在轻度病例中，直肠活检的组织学表现是非特异性的，包括粘膜水肿伴局灶性炎性细胞浸润。更严重的病例的特征是中性粒细胞浸润变性隐窝壁，在1例粘膜中有微血栓。1例患者似乎患有暴发性溃疡性结肠炎，行半结肠切除术。切除的标本显示出明显的出血和溃疡。未溃疡区域存在隐窝脓肿，但粘膜广泛坏死，粘膜和粘膜下层出血，微血栓从粘膜中的小血管延伸到粘膜下层的小静脉，与急性缺血性结肠炎中观察到的情况相似。在这种情况下，粘膜下层和粘膜中存在严重水肿和炎症。
Salmonella colitis was encountered in 8 patients. In 7, the disorder simulated ulcerative colitis clinically and radiologically. The Salmonella infection in the 8th patient was superimposed upon hitherto unrecognized ulcerative colitis. In mild cases the histological appearances of rectal biopsies were non-specific, consisting of edema of the mucosa with focal inflammatory cell infiltration. More severe cases were characterized by neutrophils infiltrating the walls of degenerating crypts and in 1 case there were microthrombi in the mucosa. One patient who appeared to have fulminant ulcerative colitis had a hemicolectomy. The resected specimen exhibited marked hemorrhage and ulceration. There were crypt abscesses in unulcerated areas but there was extensive necrosis of the mucosa, hemorrhage in the mucosa and submucosa and microthrombi extending from small vessels in the mucosa into venules in the submucosa similar to the picture seen in acute ischemic colitis. In this case there was intense edema and inflammation in the submucosa and in the mucosa.