The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs
The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs
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DOI：
10.1042/bst0351100
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发表时间：
2007-11-01
影响因子：
3.9
通讯作者：
Segal, A. W.
中科院分区：
文献类型：
--
作者：
Behe, P.;Segal, A. W.
专业吞噬细胞的NADPH氧化酶将电子传递到吞噬细胞液泡的壁上，在管腔内形成超氧化物。人们普遍认为，这一系统通过产生活性氧物种和髓过氧化物酶活性来促进微生物的杀灭。在另一种情况下，电子穿过膜改变了pH值，并产生电荷，促使离子进入和离开液泡。有人提出，酶的主要功能是产生这些pH变化和离子通量，本文讨论了围绕这些过程的问题。中性粒细胞氧化酶是存在于从植物到人类的整个生物中的一整套NOx(NAPDH氧化酶)的原型，它们可能至少部分地以类似的方式发挥作用。
The NADPH oxidase of 'professional' phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. it is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through the activity of myeloperoxidase. An alternative scenario exists in which the passage of electrons across the membrane alters the pH and generates a charge that drives ions into, and out of, the vacuole. it is proposed that the primary function of the oxidase is to produce these pH changes and ion fluxes, and the issues surrounding these processes are considered in this review. The neutrophil oxidase is the prototype of a whole family of NOXs (NAPDH oxidases) that exist throughout biology, from plants to humans, which might function, at least in part, in a similar fashion.