DIETARY CALCIUM AND VITAMIN-D - RISK-FACTORS IN THE DEVELOPMENT OF ATHEROSCLEROSIS IN YOUNG GOATS
DIETARY CALCIUM AND VITAMIN-D - RISK-FACTORS IN THE DEVELOPMENT OF ATHEROSCLEROSIS IN YOUNG GOATS
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DOI：
10.1093/jn/115.2.167
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发表时间：
1985-01-01
影响因子：
4.2
通讯作者：
LITTLEDIKE, ET
中科院分区：
文献类型：
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作者：
HINES, TG;JACOBSON, NL;LITTLEDIKE, ET
研究了日粮中添加钙和维生素D对幼山羊主动脉脂质分布和矿化的影响。2- 4只2-4周龄山羊被分配到4个日粮处理中的1个，为期20周，分别饲喂基础奶日粮（Basal）、补充钙的日粮（Basal + Ca）、富含胆钙化醇的日粮（Basal + D3）或同时添加钙和胆钙化醇的日粮（Basal + Ca + D3）。基础+钙组山羊的血浆胆固醇浓度为基础组的16.6%。总脂质的吸收百分比和粪便排泄不受饮食处理的影响。一般而言，肝脏、其他内脏和尸体组织中的总脂质和胆固醇浓度不变。膳食胆钙化醇增加的胆固醇和总脂质的浓度，而膳食钙降低总脂质的胆固醇。钙，镁和总灰分的浓度增加，通过饮食治疗，与基础+钙+ D3组中观察到的显着增加。苏丹IV和毛钙染色在Alpantas显示脂质和矿物质沉积，证实了组成数据。维生素D的高摄入伴随着钙的过量摄入似乎加速了动脉粥样硬化的发展。补充钙与正常量的维生素D是低胆固醇血症，似乎对动脉粥样硬化过程的保护。
Effcts of supplemental dietary Ca and vitamin D on lipid distribution and aortic mineralization were examined in young goats. Twenty-four goats, 2-4 wk of age, were allotted 1 of 4 dietary treatments for a 20-wk period and fed a basal milk diet (Basal), a Ca-supplemented diet (Basal + Ca), a cholecalciferol-enriched diet (Basal + D3) or a diet with both Ca and cholecalciferol (Basal + Ca + D3). Goats in the Basal + Ca group had plasma cholesterol concentrations that were 16.6% of those of the Basal group. Percentage absorption and fecal excretion of total lipids were unaffected by dietary treatment. Generally, total lipid and cholesterol concentrations were unaltered in liver, other viscera and carcass tissues. Dietary cholecalciferol increased concentrations of cholesterol and total lipid in aortas, whereas dietary Ca decreased total lipids in aortas. Concentrations of Ca, Mg and total ash were increased in aortas by dietary treatment, with a marked increase observed in the Basal + Ca + D3 group. Sudan IV and gross Ca staining in aortas revealed both lipid and mineral deposition that confirmed composition data. A high intake of vitamin D accompanied by excessive intake of Ca seems to accelerate the development of atherosclerosis. Supplemental Ca with normal amounts of vitamin D is hypocholesterolemic and seems protective against the atherogenic process.