Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
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DOI：
10.1126/science.283.5403.857
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发表时间：
1999-02-05
期刊：
影响因子：
56.9
通讯作者：
Reimann, KA
中科院分区：
文献类型：
--
作者：
Schmitz, JE;Kuroda, MJ;Reimann, KA
临床证据表明，细胞免疫参与控制人类免疫缺陷病毒-1 （HIV-1）的复制。一种获得性免疫缺陷综合征（AIDS）的动物模型——猴免疫缺陷病毒（SIV）感染恒河猴，被用来证明在原发性SIV感染期间，在CD8（+）淋巴细胞耗尽的猴子中，病毒复制不受控制。在慢性SIV感染期间，消除猴子体内的CD8（+）淋巴细胞导致病毒血症迅速显著增加，病毒血症再次被抑制，与SIV特异性CD8(+) T细胞的重新出现一致。这些结果证实了细胞介导免疫在控制HIV-1感染中的重要性，并支持探索疫苗接种方法来预防感染，从而引发这些免疫反应。
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8(+) Lymphocytes during primary SIV infection. Eliminating CD8(+) lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8(+) T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.