Ultrasonic enhancement of antibiotic action on several species of bacteria
Ultrasonic enhancement of antibiotic action on several species of bacteria
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DOI：
10.2323/jgam.44.283
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发表时间：
1998-08-01
影响因子：
1.2
通讯作者：
Pitt, WG
中科院分区：
文献类型：
--
作者：
Rediske, AM;Hymas, WC;Pitt, WG
研究了庆大霉素、链霉素、卡那霉素、四环素和氨苄西林等抗生素对70 kHz超声波作用前后产气肠杆菌、粘质沙雷氏菌、德比沙门氏菌、中型链球菌和表皮葡萄球菌浮游培养的影响。在对浮游细菌培养没有抑制作用的水平上施加超声波。在上述抗生素对浮游细菌培养物的最低抑菌浓度以下、高于或高于最低抑菌浓度时的活力测量表明，同时应用70 kHz超声波和抗生素显著提高了选定抗生素的有效性。当无害的超声波水平与一些抗生素，特别是氨基糖苷类药物结合时，细菌的生存能力会下降几个数量级。在革兰氏阳性菌和革兰氏阴性菌与几种抗生素的联合治疗中，超声和抗生素的联合治疗具有相似的协同效应，这些结果可能适用于对某些抗生素正常耐药的细菌感染的治疗。
The effect of the antibiotics gentamicin, streptomycin, kanamycin, tetracycline, and ampicillin on planktonic cultures of Enterobacter aerogenes, Serratia marcescens, Salmonella derby, Streptococcus mitis, and Staphylococcus epidermidis with and without an application of 70 kHz ultrasound was studied. The ultrasound was applied at levels that had no inhibitory effect on planktonic cultures of bacteria. Measurements of viability at, above, and below the minimum inhibitory concentration of the above antibiotics on the planktonic cultures of these bacteria showed that a simultaneous application of 70 kHz ultrasound and antibiotic significantly increased the effectiveness of selected antibiotics. Bacterial viability was reduced several orders of magnitude when harmless levels of ultrasound were combined with some antibiotics, especially the aminoglycosides. Similar synergistic effects of combined ultrasound and antibiotic treatment were seen in both Gram-positive and Gram-negative bacteria with several classes of antibiotics, These results may have application in the treatment of bacterial infections normally resistant to some antibiotics.