Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine
Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine
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DOI：
10.7861/clinmed.2020-0552
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发表时间：
2021-03-01
影响因子：
4.4
通讯作者：
Shah, Benoy N.
中科院分区：
文献类型：
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作者：
Hinton, Jonathan;Reeves, Thomas;Shah, Benoy N.
目标 我们旨在评估指南委员会作者和用于支持欧洲心脏病学会 (ESC) 指南的研究作者之间经济利益冲突的频率和性质。 设计 我们评估了撰写 5 个关键 ESC 临床实践指南 (CPG) 的医生之间的利益冲突：瓣膜性心脏病 (VHD)、心房颤动 (AF)、心包疾病 (PD)、心力衰竭 (HF) 和心肌血运重建 (IHD)。此外，我们还检查了建议中引用的与药剂相关的研究的资金来源。如果一项研究由行业赞助，则会审查所有作者的披露，以评估是否与研究资助者存在财务利益冲突。结果 五个指南中总共有 603 条建议（PD 112、VHD 111、HF 169、IHD 97 和 AF 114），其中 271 条（45%（PD 26、VHD 23、HF 72、IHD） 84 和 AF 66)) 与药剂有关。除 PD 指南外，至少 80% 的指南委员会作者存在相关的财务利益冲突，其中最常见的是直接个人付款 (68-82%)。行业对研究的支持率在指南中各不相同，从 5% (PD) 到 65% (IHD) 不等。如果一项研究由行业资助，作者经常（55-90%）与行业赞助商发生冲突。结论 大多数撰写临床指南的医生都存在相关的财务利益冲突。此外，行业对研究的赞助很常见，作者经常与研究资助者发生冲突。我们建议编写临床指南的医生应避免此类经济利益冲突，以保持临床指南的科学完整性和独立性。
Objectives We aimed to assess the frequency and nature of financial conflicts of interest among both the guideline committee authors and the authors of research studies used to support the European Society of Cardiology (ESC) guidelines.Design We evaluated the competing interests of the doctors that write five of the key ESC clinical practice guidelines (CPG): valvular heart disease (VHD), atrial fibrillation (AF), pericardial diseases (PD), heart failure (HF) and myocardial revascularisation (IHD). In addition, we examined the funding sources of studies cited in the recommendations that were related to pharmaceutical agents. If a study was sponsored by industry, the disclosures of all authors were reviewed to assess whether there was a financial conflict of interest with the study funder.Results In total, there were 603 recommendations (PD 112, VHD 111, HF 169, IHD 97 and AF 114) across the five guidelines, of which, 271 (45% (PD 26, VHD 23, HF 72, IHD 84 and AF 66)) related to pharmaceutical agents. At least 80% of guideline committee authors, except for the PD guidelines, had a relevant financial conflict of interest, with the most frequent being a direct personal payment (68-82%). Industry support for studies varied across the guidelines from 5% (PD) to 65% (IHD). If a study was funded by industry, authors were frequently (55-90%) conflicted with the industry sponsor.Conclusions The majority of the doctors that write clinical guidelines have a relevant financial conflict of interest. In addition, industry sponsorship of studies is frequent, and authors are often conflicted with the study funder. We propose that physicians that write clinical guidelines should be free of such financial conflicts of interest to maintain scientific integrity and independence in the clinical guidelines.